Results 91 to 100 of about 20,465 (306)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Scientific computation of conservation laws in the calculus of variations and optimal control
, 2005 We present analytic computational tools that permit us to identify, in an automatic way, conservation laws in optimal control. The central result we use is the famous Noether’s theorem, a classical theory developed by Emmy Noether in 1918, in the ...
Gouveia, Paulo D.F., Torres, Delfim F.M.
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Advances in Nonlinear Analysis, 2017 The core of this paper concerns the existence (via regularity) of weak solutions in W01,2${W_{0}^{1,2}}$ of a class of elliptic systems such ...
Boccardo Lucio, Orsina Luigi
doaj +1 more source
Nonsmooth Problems of Calculus of Variations via Codifferentiation [PDF]
, 2014 In this paper multidimensional nonsmooth, nonconvex problems of the calculus of variations with codifferentiable integrand are studied. Special classes of codifferentiable functions, that play an important role in the calculus of variations, are ...
Maxim Dolgopolik, Dolgopolik, Maxim
core +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Gauge symmetries and Noether currents in optimal control
, 2003 We extend the second Noether theorem to optimal control problems which are invariant under symmetries depending upon k arbitrary functions of the independent variable and their derivatives up to some order m.
Torres, D.F.M.
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Fractional Calculus of Variations for Composed Functionals with Generalized Derivatives
Fractal and FractionalThis paper extends the fractional calculus of variations to include generalized fractional derivatives with dependence on a given kernel, encompassing a wide range of fractional operators.
Ricardo Almeida
doaj +1 more source
Optimal Feeding Trajectories Design for E. coli Fed-batch Fermentations [PDF]
International Journal Bioautomation, 2010 In this paper optimal control algorithms for two E. coli fed-batch fermentations are developed. Fed-batch fermentation processes of E. coli strain MC4110 and E. coli strain BL21(DE3)pPhyt109 are considered.
Olympia Roeva +2 more
doaj