Results 111 to 120 of about 166,028,341 (301)

Optimizing Variational Problems through Weighted Fractional Derivatives

Fractal and Fractional
In this article, we explore a variety of problems within the domain of calculus of variations, specifically in the context of fractional calculus. The fractional derivative we consider incorporates the notion of weighted fractional derivatives along with
Ricardo Almeida
doaj   +1 more source

A Calculus for Variational Programming.

, 2016
Variation is ubiquitous in software. Many applications can benefit from making this variation explicit, then manipulating and computing with it directly---a technique we call "variational programming". This idea has been independently discovered in several application domains, such as efficiently analyzing and verifying software product lines ...
Chen, Sheng, Erwig, Martin, Walkingshaw, Eric   +2 more
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Symbolic computation of variational symmetries in optimal control [PDF]

, 2006
We use a computer algebra system to compute, in an efficient way, optimal control variational symmetries up to a gauge term. The symmetries are then used to obtain families of Noether’s first integrals, possibly in the presence of nonconservative ...
Gouveia, Paulo D.F., Torres, Delfim F.M., Rocha, Eugénio A.M.   +2 more
core  

Exploring Variational Methods in Hydro- and Hemodynamics Through Incompressible Velocity Distribution Sampling

IEEE Access
Artificial neural networks are a robust tool for approximating spatial and temporal functions. This study introduces a novel method for hydro- and hemodynamics based on the minimization of a power loss.
Ivan Stebakov, Alexei Kornaev, Elena Kornaeva, Sergey Majorov   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Calculus of variations

, 1961
Calculus of Variations aims to provide an understanding of the basic notions and standard methods of the calculus of variations, including the direct methods of solution of the variational problems. The wide variety of applications of variational methods
Elsgolc, L E, Stark, M, Sneddon, I N
core  

A Study of the Calculus of Variations

, 2009
This thesis is an introductory study of the calculus of variations. We will begin by introducing the field of the calculus of variations, its history and describe the classical problems of the calculus of variations.
Willert, Jeffrey Alan
core   +1 more source