Results 121 to 130 of about 166,028,341 (301)
Fractional Euler–Lagrange Equations Under Periodic and Antiperiodic Boundary Conditions
Fractal and FractionalIn this work, we derive necessary optimality conditions for a class of fractional variational problems involving Caputo-type derivatives. We consider functionals defined on appropriate spaces of absolutely continuous functions and study both periodic and
Ricardo Almeida
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Determination of obstacles in Stokes flow by boundary measurement
Electronic Journal of Differential Equations, 2017 We study the determination of some obstacles in a Stokes flow domain with overdetermined boundary data. We use a method based on the topological sensitivity technique associated to the reciprocity gap function concept. We develop an asymptotic formula
Mohamed Abdelwahed +2 more
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
On the inequality of weierstrass for nonlocal functionals
Journal of Inequalities and Applications, 2001 The aim of this paper is to consider the problem of extremum of the nonlocal functional, which depends on a function and its derivative with respect to at several values of .
Kamenskii GA, Zabrodina Ju P
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
On the generalized fractal calculus of variations
In this paper, we provide a brief overview of fractal calculus and present a comprehensive study of the calculus of variations for functionals on fractal sets.
Furuichi, Shigeru +3 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Was the Early Calculus an Inconsistent Theory? [PDF]
, 2007 The ubiquitous assertion that the early calculus of Newton and Leibniz was an inconsistent theory is examined. Two different objects of a possible inconsistency claim are distinguished: (i) the calculus as an algorithm; (ii) proposed explanations of the ...
Vickers, Peter
core