Results 51 to 60 of about 1,220,933 (279)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Empirical Evaluations of Framework for Adaptive Trust Calibration in Human-AI Cooperation

IEEE Access, 2020
Recent advances in AI technologies are dramatically changing the world and impacting our daily life. However, human users still essentially need to cooperate with AI systems to complete tasks as such technologies are never perfect.
Kazuo Okamura, Seiji Yamada
doaj   +1 more source

Reducing BCI calibration time with transfer learning: a shrinkage approach [PDF]

, 2016
Introduction: A brain-computer interface system (BCI) allows subjects to make use of neural control signals to drive a computer application. Therefor a BCI is generally equipped with a decoder to differentiate between types of responses recorded in the ...
Dambre, Joni, Kindermans, Pieter-Jan, Vandenberghe, Stefaan, Verhoeven, Thibault   +3 more
core   +1 more source

A Landmark Calibration Based IP Geolocation Approach [PDF]

2015 10th International Conference on Availability, Reliability and Security, 2015
Aiming at the existing IP geolocation approaches does not consider the errors of landmarks and delay; a new geolocation approach-utilized landmark calibration is proposed in this paper. At first, we find out these landmarks shared the nearest common router with a target IP by path detection; second, a deviation is assigned to each related landmark ...
Chen, Jingning, Liu, Fenlin, Luo, Xiangyang, Zhao, Fan, Zhu, Guang   +4 more
openaire   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Optical System Error Analysis and Calibration Method of High-Accuracy Star Trackers

Sensors, 2013
The star tracker is a high-accuracy attitude measurement device widely used in spacecraft. Its performance depends largely on the precision of the optical system parameters.
Zheng You, Fei Xing, Ting Sun
doaj   +1 more source

RegNet: Multimodal Sensor Registration Using Deep Neural Networks

, 2017
In this paper, we present RegNet, the first deep convolutional neural network (CNN) to infer a 6 degrees of freedom (DOF) extrinsic calibration between multimodal sensors, exemplified using a scanning LiDAR and a monocular camera.
Franke, Uwe, Piewak, Florian, Schneider, Nick, Stiller, Christoph   +3 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Quality Assessment of Satellite Data for Rainfall Estimation using Streamflow Simulation in Hydrological Modeling (Case Study: the Tighsiah Catchment) [PDF]

پژوهشنامه مدیریت حوزه آبخیز
Extended Abstract Background: Precipitation is one of the most critical inputs in hydrological models. Due to its significant spatiotemporal variability, high-resolution temporal and spatial data are required for accurate hydrological modeling.
Pedram Sodagar
doaj  

Antenna Array Calibration Using a Sparse Scene

IEEE Open Journal of Antennas and Propagation, 2021
In radar systems, antenna arrays acquire direction-dependent information to localize targets or create images of the environment. However, because of unknown complex amplitudes per channel and mutual coupling, a calibration is necessary for good ...
Johanna Geiss, Erik Sippel, Markus Hehn, Martin Vossiek   +3 more
doaj   +1 more source