Results 101 to 110 of about 5,467,731 (352)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Revisió taxonòmica i ecològica dels Delphinium de Califòrnia
Collectanea Botanica, 1990 [ca] A l'interior dels límits de Califòrnia es troben la totalitat o parts de les àrees de bona part dels Delphinium nadius de Nordamèrica. Es reconeixen 28 espècies de Delphinium a Califòrnia; ultra llurs respectives subspècies nominals, es reconeixen ...
Michael J. Warnock
doaj +1 more source
Caltech and aeronautics: a presentation by the California Institute of Technology [PDF]
, 1958 The outstanding accomplishment of Caltech in the field of aeronautics is not that it has taught, but that it has always had something new to teach. When most aircraft were glued together from bamboo, balsawood, and canvas, Caltech was teaching the next ...
California, Institute of Technology
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Patient Experience JournalObjective: The COVID-19 pandemic subjected healthcare systems' to decreasing operational margins, enhanced regulatory scrutiny, and challenges related to patients' expectations.
Nancy Valla
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
International Lessons for Promoting Transit Connections to High-Speed Rail Systems [PDF]
, 2016 As the California High-Speed Rail (HSR) project becomes reality, many communities involved in, or affected by, the California HSR project have considered how to connect the new HSR passenger services to local urban transportation systems – such as bus ...
Feinsod, Stan +3 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Los bandidos y la identidad california en la segunda mitad del XIX: Tiburcio Vasquez
Revista de Indias, 2016 El bandido Tiburcio Vasquez desarrolla su carrera en un momento de dificultad política y social para los californios, que desde 1848 pasan a formar parte de EEUU. Se examinan la entrevista bilingüe que Vasquez concede en la víspera de su ajusticiamiento,
Covadonga Lamar Prieto
doaj +1 more source