Results 151 to 160 of about 5,999,398 (314)

Telephone Triage for Medical Students: An Exploration Through Cultural Historical Activity Theory. [PDF]

Clin Teach
Mawhood J, Mackie E, Merritt K, Donkin J, Fisher J.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Emergency department attendance by callers to NHS111 who end the call prior to triage: A time-to-event-analysis. [PDF]

PLoS One
Pilbery R, Lewis J, Simpson R.
europepmc   +1 more source

Modest growth in West for 1987 and 1988 [PDF]

Federal Reserve District, 12th ; Economic conditions - West (U.S.)
Carolyn Sherwood-Call
core  

First human fatality from H5N2 virus: Have we learnt lessons in pandemic preparedness?

New Microbes and New Infections
Faithful Miebaka Daniel, Victoria Ezinne Emeruwa, Lydia Daopuye   +2 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Evaluation of Routine Clinical Deployment of an Autonomous Artificial Intelligence Assistant for Cataract Follow-Up in the National Health Service. [PDF]

Clin Ophthalmol
Higham A, Sideri AM, Tarcoveanu F, Lim EJ, Bijma LHG, Imtiyaz SS, Stacey LK, Khavandi S, de Pennington N, Thomas J, Adams M, Maling SJ, Arun KS, Turner R, King C, Xue K.   +15 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Rainfall and Temperature Explain Colony Variation in Echolocation Calls of the Intermediate Horseshoe Bats (<i>Rhinolophus affinis</i>). [PDF]

Ecol Evol
Guo D, Wang L, Zhang C, Dong S, Wang F, Luo B, Liu S.   +6 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source