Results 71 to 80 of about 1,386,571 (318)
Simulation in the call-by-need lambda-calculus with letrec [PDF]
, 2010 This paper shows the equivalence of applicative similarity and contextual approximation, and hence also of bisimilarity and contextual equivalence, in the deterministic call-by-need lambda calculus with letrec.
Sabel, David +2 more
core +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
, 2015 This edition of the CALL Insider includes descriptions of recent CALL activities, updates from training centers, and other CALL-related ...
Center for Army Lessons Learned
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, 2017 Background: 'Call' is a 40-minute solo live performance presented in the international 'Performing, Writing' program directed by Julieanna Preston. It was presented to the public at Bats Theatre, Wellington's home of independent theatre as part of The ...
Mick Douglas (18044032)
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Наукові записки НаУКМА. Комп'ютерні науки, 2020 The goal of this work is to practically apply methods of empirical engineering software, algorithms for data collection and data analysis. The results include software measurement, analysis and selection of direct and indirect metrics for research and ...
Andrii Hlybovets, Oleksandr Shapoval
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2017 Highlights for this issue of the CALL Insider include two catalogs we produced last month based on topics trending in the Army community. Subterranean Ops and Counter-Weapons of Mass Destruction both provide the user with a compilation of doctrine ...
Center for Army Lessons Learned
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