Results 31 to 40 of about 9,518 (289)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

New call blocking probability (NCBP) in improved adaptive quality of service (AdQoS) for wireless multimedia communications using hierarchical cellular approach [PDF]

, 2003
The maintenance of quality of service (QoS) in a wireless environment is a difficult problem. Most researchers have already acknowledged adaptive techniques as the appropriate method to deal with the fluctuation of QoS in a wireless cellular network ...
Prihandoko,, Prakash, Veeraraghavan, Mohd Ali, Borhanuddin, Sahbudin, Ratna Kalos Zakiah, Kandasamy, Saravanan   +4 more
core   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

What Do Large Language Models Know About Materials?

Advanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer, Thomas Wallmersperger, Gianaurelio Cuniberti   +2 more
wiley   +1 more source

Networking model and traffic analysis for integrating ad hoc and LEO satellite terminals

Tongxin xuebao, 2006
The compromise between the utilization rate of valuable satellite channels and the blocking probability of new call was hardly to achieve.Enlightened by the advantages of ad hoc networking,a new scheme was proposed which al-lowed the terminals to work in
WANG Xiao-yan, WANG Hao, DONG Yan, HUANG Zai-lu   +3 more
doaj   +2 more sources

Additive Gaussian Process Regression for Predictive Design of High‐Performance, Printable Silicones

Advanced Engineering Materials, EarlyView.
A chemistry‐aware design framework for tuning printable polydimethylsiloxane (PDMS) for vat photopolymerization (VPP) is developed using additive Gaussian process (GP) modeling. Polymer network mechanics informs variable groupings, feasible formulation constraints, and interaction variables.
Roxana Carbonell, Martha Leach, Hongtao Song, Carolyn Seepersad   +3 more
wiley   +1 more source

A Novel Call Admission Control Policy Using Mobility Prediction and Throttle Mechanism for Supporting QoS in Wireless Cellular Networks

Journal of Control Science and Engineering, 2011
The decision of call admission becomes an important work owing to the scarce wireless spectrum for wireless cellular networks. If there exists adequate information for call admission control (CAC) schemes, the terms of quality of service (QoS), such as ...
Chen-Feng Wu, Liang-Teh Lee, Hung-Yuan Chang, Der-Fu Tao   +3 more
doaj   +1 more source

Fixed capacity and variable member grouping assignment of orthogonal variable spreading factor code tree for code division multiple access networks

The Journal of Engineering, 2014
Orthogonal variable spreading factor codes are used in the downlink to maintain the orthogonality between different channels and are used to handle new calls arriving in the system. A period of operation leads to fragmentation of vacant codes. This leads
Vipin Balyan, Davinder S Saini, Ankit Mehta   +2 more
doaj   +1 more source