Results 51 to 60 of about 144,490 (266)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

The Mutationathon highlights the importance of reaching standardization in estimates of pedigree-based germline mutation rates

eLife, 2022
In the past decade, several studies have estimated the human per-generation germline mutation rate using large pedigrees. More recently, estimates for various nonhuman species have been published.
Lucie A Bergeron, Søren Besenbacher, Tychele Turner, Cyril J Versoza, Richard J Wang, Alivia Lee Price, Ellie Armstrong, Meritxell Riera, Jedidiah Carlson, Hwei-yen Chen, Matthew W Hahn, Kelley Harris, April Snøfrid Kleppe, Elora H López-Nandam, Priya Moorjani, Susanne P Pfeifer, George P Tiley, Anne D Yoder, Guojie Zhang, Mikkel H Schierup   +19 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Detailed comparison of two popular variant calling packages for exome and targeted exon studies [PDF]

PeerJ, 2014
The Genome Analysis Toolkit (GATK) is commonly used for variant calling of single nucleotide polymorphisms (SNPs) and small insertions and deletions (indels) from short-read sequencing data aligned against a reference genome.
Charles D. Warden, Aaron W. Adamson, Susan L. Neuhausen, Xiwei Wu   +3 more
doaj   +2 more sources

Forecasting emergency medical service call arrival rates

The Annals of Applied Statistics, 2011
We introduce a new method for forecasting emergency call arrival rates that combines integer-valued time series models with a dynamic latent factor structure. Covariate information is captured via simple constraints on the factor loadings. We directly model the count-valued arrivals per hour, rather than using an artificial assumption of normality ...
Matteson, David S., McLean, Mathew W., Woodard, Dawn B., Henderson, Shane G.   +3 more
openaire   +3 more sources

Minimum Rate Guaranteed Call Admission Control for Cumulative Rate Distribution Based Scheduling [PDF]

IEEE Communications Letters, 2011
In this letter, we investigate call admission control (CAC) for cumulative rate distribution based scheduling (CS) in wireless communication networks. We first analyze the multi-user diversity gain (MDG) of CS, which is applicable to general channel conditions. Then we propose the minimum rate guaranteed CS/ORR based CAC algorithm, COCAC, which jointly
Hao Wang, Lianghui Ding, Nan Liu, Zhiwen Pan, Ping Wu, Xiaohu You   +5 more
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Accurate and scalable variant calling from single cell DNA sequencing data with ProSolo

Nature Communications, 2021
Obtaining accurate variant calls from multiple displacement amplified single cell DNA sequencing data needs dedicated models that account for amplification bias and copy errors.
David Lähnemann, Johannes Köster, Ute Fischer, Arndt Borkhardt, Alice C. McHardy, Alexander Schönhuth   +5 more
doaj   +1 more source

Examination of call setup success rate and dropped call rate for 4g networks in Yenagoa-southern Nigeria

World Journal of Advanced Research and Reviews
This study compares the call setup success rate and dropped call rate of four mobile telecommunication networks operating in Yenagoa, Southern Nigeria, to industry benchmarks and competitor networks in an effort to identify areas for improvement, set performance targets, and establish a relationship between them. The results show that the four networks
Nnenna Juliet Chidiebere, Chibuzo Emeruwa   +1 more
openaire   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source