Results 301 to 310 of about 844,015 (339)
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Molecular Aspects of Medicine, 2011
Restricting the intake of calories has been practiced as a method for increasing both the length and quality of life for over 500 years. Experimental work confirming the success of this approach in animals has accumulated over the last 100 years. Lifelong caloric restriction (CR) may extend life by up to 50% in rodents, with progressively less impact ...
John R, Speakman, Sharon E, Mitchell
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Restricting the intake of calories has been practiced as a method for increasing both the length and quality of life for over 500 years. Experimental work confirming the success of this approach in animals has accumulated over the last 100 years. Lifelong caloric restriction (CR) may extend life by up to 50% in rodents, with progressively less impact ...
John R, Speakman, Sharon E, Mitchell
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Caloric Restriction in Primates
Annals of the New York Academy of Sciences, 2001Abstract:Caloric restriction (CR) remains the only nongenetic intervention that reproducibly extends mean and maximal life span in short‐lived mammalian species. This nutritional intervention also delays the onset, or slows the progression, of many age‐related disease processes. The diverse effects of CR have been demonstrated many hundreds of times in
M A, Lane +5 more
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The effect of caloric restriction on working memory in healthy non-obese adults
CNS Spectrums, 2020Objective. We aim to evaluate the effect of caloric restriction (CR) in cognition by comparing performance in neuropsychological tests for working memory between a group of non-obese healthy subjects doing CR for 2 years with another consuming ad libitum
Emilie Leclerc +6 more
semanticscholar +1 more source
Food & Function, 2020
Alzheimer's disease (AD) is a neurodegenerative disorder that commonly occurs among older individuals. Increasing evidence suggests that a low-caloric diet might be a promising adjuvant therapeutic strategy for slowing or preventing the pathogenesis and ...
Yi Yang, Lihui Zhang
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Alzheimer's disease (AD) is a neurodegenerative disorder that commonly occurs among older individuals. Increasing evidence suggests that a low-caloric diet might be a promising adjuvant therapeutic strategy for slowing or preventing the pathogenesis and ...
Yi Yang, Lihui Zhang
semanticscholar +1 more source
Science Signaling, 2009
A signaling pathway in mice mediates the effects of caloric restriction that protect against age-related diseases.
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A signaling pathway in mice mediates the effects of caloric restriction that protect against age-related diseases.
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Proteolysis, caloric restriction and aging
Mechanisms of Ageing and Development, 2001The nature of the aging process has been the subject of considerable speculation. It is believed that free radical damage to cellular components is one of the main contributors to the aging process. Studies on proteins have shown age-related decline in enzyme activities, age-related accumulation of oxidized proteins and a decline of the proteolytic ...
K, Merker, A, Stolzing, T, Grune
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Science's STKE, 2003
Restricting calories extends the life-span of various organisms. In the yeast Saccharomyces cerevisiae , this depends upon increased activity of Sir2, a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase.
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Restricting calories extends the life-span of various organisms. In the yeast Saccharomyces cerevisiae , this depends upon increased activity of Sir2, a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase.
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Slowing ageing by caloric restriction
Nature Medicine, 1995Dietary caloric restriction is the only intervention conclusively shown to slow ageing, delay the onset of age-related diseases, maintain function and extend both median and maximal life span in mammals.
G S, Roth, D K, Ingram, M A, Lane
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