Results 311 to 320 of about 844,015 (339)
Some of the next articles are maybe not open access.
2007
Caloric restriction remains the only nongenetic intervention that has been consistently and reproducibly shown to extend both average and maximal lifespan in a wide variety of species. If shown to be applicable to human aging, it is unlikely that most people would be able to maintain the 30-40% reduction in food intake apparently required for this ...
Mark A. Lane +2 more
openaire +1 more source
Caloric restriction remains the only nongenetic intervention that has been consistently and reproducibly shown to extend both average and maximal lifespan in a wide variety of species. If shown to be applicable to human aging, it is unlikely that most people would be able to maintain the 30-40% reduction in food intake apparently required for this ...
Mark A. Lane +2 more
openaire +1 more source
Caloric restriction and brain function
Current Opinion in Clinical Nutrition and Metabolic Care, 2008In addition to extending lifespan, animal research shows that specific diets benefit brain functioning. Indeed, it has been proven that caloric restriction prevents age-related neuronal damage. What are those mechanisms involved in the effects of caloric restriction on brain functioning? Could caloric restriction be proposed in the future to prevent or
Sophie, Gillette-Guyonnet, Bruno, Vellas
openaire +2 more sources
Science of Aging Knowledge Environment, 2003
Caloric (or dietary) restriction (CR) is the most potent, robust, and reproducible known means of extending longevity and decreasing morbidity in laboratory mammals. Two of the major questions faced by researchers in this field are the applicability to humans and the biochemical mechanism(s) involved in the actions of CR.
Bruce S, Kristal, Ugo, Paolucci
openaire +2 more sources
Caloric (or dietary) restriction (CR) is the most potent, robust, and reproducible known means of extending longevity and decreasing morbidity in laboratory mammals. Two of the major questions faced by researchers in this field are the applicability to humans and the biochemical mechanism(s) involved in the actions of CR.
Bruce S, Kristal, Ugo, Paolucci
openaire +2 more sources
Caloric Restriction and Toxicity
Toxicological Sciences, 1995Caloric Restriction and Toxicity. Hart, R. W., Keenan, K., Turturro, A., Abdo, K. M. Leakey, J., Lyn-Cook, B. (1995). Fundam. Appl. Toxicol. 25, 184-195. The modulatory effects of caloric intake on the rate and extent of both spontaneous and induced disease incidence is well known, but the significance of these effects in the interpretation of ...
RONALD W. HART +5 more
openaire +2 more sources
The antitumour effects of caloric restriction are mediated by the gut microbiome
Nature Metabolism, 2023Yu-qin Mao +11 more
semanticscholar +1 more source
Caloric Restriction, Gene Expression, and Aging
Alzheimer Disease & Associated Disorders, 2003Abstract Caloric restriction (CR) increases maximum life span in many species. In laboratory rodents, CR started either early in life or in middle-age opposes the development of age-associated biological and pathological changes. Three main questions are being asked by CR investigators. How does CR retard aging and disease processes?
openaire +2 more sources
Scientific American sp, 1996
The relationship between eating less and greater longevity is explored. The author notes that eating less but ensuring an adequate supply of protein fat vitamins and minerals has been shown to improve the health and longevity of rodents. The relevance of these findings to humans is considered. (ANNOTATION)
openaire +2 more sources
The relationship between eating less and greater longevity is explored. The author notes that eating less but ensuring an adequate supply of protein fat vitamins and minerals has been shown to improve the health and longevity of rodents. The relevance of these findings to humans is considered. (ANNOTATION)
openaire +2 more sources
Caloric Restriction and Caloric Restriction Mimetics: Current Status and Promise for the Future
Journal of the American Geriatrics Society, 2005Dietary caloric restriction is the most reproducible means of extending longevity and maintaining health and vitality. It has been shown to be relevant to a wide rage of species, including primates. Examination of key markers of the calorically restricted phenotype, such as plasma insulin, dehydroepiandrosterone sulfate, and body temperature, suggest ...
openaire +2 more sources
Caloric Restriction and Cancer
2010In various animal models, caloric restriction is the most effective and reproducible intervention to extend life span and to reduce risks of aging-related chronic diseases, particularly cancer. Findings from human studies based on ecologic comparisons, the Norwegian famine during World War II, and patients with anorexia nervosa suggest that caloric ...
Fei Xue, Karin B. Michels
openaire +1 more source