Results 81 to 90 of about 109,301 (302)
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
The functional status of the human vestibular analysor following 56 days in an aqueous immersion medium [PDF]
Two male volunteers were kept hypokinetic in the immersion and physiological parameters were evaluated following the experiment. Prophylactic measures (g-forces, physical exercises, and supplementary salt and water) were applied daily.
Matsnev, E. I., Shulzhenko, Y. B.
core +1 more source
Microscopic systems with and without Coulomb interaction, fragmentation and phase transitions in finite nuclei [PDF]
, 2001 We test the influence of the Coulomb interaction on the thermodynamic and cluster generation properties of a system of classical particles described by different lattice models. Numerical simulations show that the Coulomb interaction produces essentially
Carmona, J. M., Richert, J., Wagner, P.
core +4 more sources
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Astrophysical fluid simulations of thermally ideal gases with non-constant adiabatic index: numerical implementation [PDF]
, 2015 An Equation of State (\textit{EoS}) closes the set of fluid equations. Although an ideal EoS with a constant \textit{adiabatic index} $\Gamma$ is the preferred choice due to its simplistic implementation, many astrophysical fluid simulations may benefit ...
Bodo, G. +3 more
core +2 more sources
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Vestibular dysfunction in lateral semicircular canal dysplasia
Frontiers in NeurologyIntroductionLateral semicircular canal (LSCC) dysplasia is the most common inner ear malformation. The severity of dysplasia can appear in various spectrums, from a short and broad LSCC with normal or small-sized central bony island (CBI) to a single ...
Ji Min Yun +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Phase space characteristics of fragmenting nuclei described as excited disordered systems [PDF]
, 1996 We investigate the thermodynamical content of a cellular model which describes nuclear fragmentation as a process taking place in an excited disordered system.
Boose, D. +3 more
core +3 more sources