Results 71 to 80 of about 109,301 (302)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Antioxidant/Anti-Inflammatory Effects of Caloric Restriction in an Aged and Obese Rat Model: The Role of Adiponectin

Biomedicines, 2020
Caloric restriction (CR) represents a powerful intervention for extending healthspan and lifespan in several animal models, from yeast to primates. Additionally, in humans, CR has been found to induce cardiometabolic adaptations associated with improved ...
Daniele La Russa, Alessandro Marrone, Maurizio Mandalà, Rachele Macirella, Daniela Pellegrino   +4 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Bedside differentiation of vestibular neuritis from central "vestibular pseudoneuritis". [PDF]

, 2008
Acute unilateral peripheral and central vestibular lesions can cause similar signs and symptoms, but they require different diagnostics and management.
Brandt, Thomas, Cnyrim, C. D., Karch, C., Newman-Toker, D., Strupp, Michael   +4 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Labyrinthine defects as shown by ataxia and caloric tests [PDF]

Labyrinthine defects as shown by ataxia and caloric ...
Fregly, A. R., Graybiel, A.
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Isotopic Dependence of the Nuclear Caloric Curve [PDF]

, 2009
The A/Z dependence of projectile fragmentation at relativistic energies has been studied with the ALADIN forward spectrometer at SIS. A stable beam of 124Sn and radioactive beams of 124La and 107Sn at 600 MeV per nucleon have been used in order to ...
Adrich, P., Aumann, T., Bacri, C. O., Barczyk, T., Bassini, R., Bianchin, S., Boiano, C., Botvina, A. S., Boudard, A., Brzychczyk, J., Chbihi, A., Cibor, J., Czech, B., De Napoli, M., Ducret, J. -E., Emling, H., Fevre, A. Le, Frankland, J. D., Gentil, E. Le, Hellstroem, M., Henzlova, D., Imme, G., Iori, I., Johansson, H., Kezzar, K., Lafriakh, A., Leifels, Y., Luehning, J., Lukasik, J., Lynch, W. G., Lynen, U., Majka, Z., Mocko, M., Mueller, W. F. J., Mykulyak, A., Orth, H., Otte, A. N., Palit, R., Pawlowski, P., Pullia, A., Raciti, G., Rapisarda, E., Sann, H., Schwarz, C., Sfienti, C., Simon, H., Suemmerer, K., The ALADIN2000 Collaboration, Trautmann, W., Tsang, M. B., Verde, G., Volant, C., Wallace, M., Weick, H., Wiechula, J., Wieloch, A., Zwieglinski, B.   +56 more
core   +4 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

High-Frequency Vestibular Function Is Vulnerable to Presbyvestibulopathy

Diagnostics
Introduction: In 2019, mild vestibular function deficiency in elder populations was defined as presbyvestibulopathy (PVP) by the Classification Committee of the Bárány Society.
Seonghoon Bae, Jimin Yun, Seungmin Kwak, Hyuntaek Jung, Hancheol Lee, Juyoung Kim, Chanhee Kim, Yujin Lee, Sunghuhn Kim   +8 more
doaj   +1 more source