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Calorie Restriction and Aging in Humans

Annual Review of Nutrition, 2020
Calorie restriction (CR), the reduction of dietary intake below energy requirements while maintaining optimal nutrition, is the only known nutritional intervention with the potential to attenuate aging. Evidence from observational, preclinical, and clinical trials suggests the ability to increase life span by 1–5 years with an improvement in health ...
Flanagan, E.W.   +5 more
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Calorie restriction and cardiometabolic health

European Journal of Cardiovascular Prevention & Rehabilitation, 2008
An epidemic of overweight/obesity and type 2 diabetes, caused by overeating nutrient-poor energy-dense foods and a sedentary lifestyle, is spreading rapidly throughout the world. Abdominal obesity represents a serious threat to health because it increases the risk of developing many chronic diseases, including cardiovascular disease and cancer. Calorie
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Potential downsides of calorie restriction

Nature Reviews Endocrinology
Although the potential benefits of calorie restriction on human lifespan remain uncertain, it is currently one of the most extensively researched non-genetic approaches to extending both lifespan and healthspan in animals. Calorie restriction offers numerous health benefits, including a reduced incidence of age-related diseases.
Anyongqi Wang, John Roger Speakman
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Bioenergetics of aging and calorie restriction

Ageing Research Reviews, 2006
Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time.
Nicole D, Hunt   +6 more
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Calorie Restriction and Aging

Scientific American sp, 1996
The relationship between eating less and greater longevity is explored. The author notes that eating less but ensuring an adequate supply of protein fat vitamins and minerals has been shown to improve the health and longevity of rodents. The relevance of these findings to humans is considered. (ANNOTATION)
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Calorie Restriction and Aging

Blood, 2010
Abstract Abstract SCI-2 A prominent manifestation of aging is a reduced ability to respond to environmental stressors, including heat and oxidative stress. Reduced stress tolerance and decreased ability to maintain homeostasis are at least partially responsible for the increased morbidity and mortality that occurs with ...
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Calorie Restriction and Obesity

2010
Dietary restriction regimens are commonly employed to facilitate weight loss in obese individuals. The dietary restriction regimen most frequently implemented is daily calorie restriction (CR), which involves decreasing energy intake by a certain percentage daily.
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Calorie Restriction Mimetics and Aging

2010
Various polyphenols found in plants are able to activate biochemical pathways in mammalian cells so as to confer health benefits. These molecules include resveratrol, catechins, quercetin and genistein. There is considerable overlap between these pathways and those activated by caloric restriction.
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Calorie Restriction in Humans

2016
Eric Ravussin   +2 more
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