Results 31 to 40 of about 34,470 (288)
Sir2-independent life span extension by calorie restriction in yeast.
PLoS Biology, 2004 Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2.
Matt Kaeberlein +3 more
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Calorie Restriction à Lamarck [PDF]
Cell, 2014 Epigenetic inheritance of resistance to exogenous nucleic acids via small interfering (si) RNA is well established in animal models. Rechavi et al. demonstrate epigenetic inheritance of a starvation-induced pattern of gene silencing caused by endogenous siRNAs and resulting in an increased longevity in the third generation progeny. Combined with recent
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Calorie restriction in rhesus monkeys [PDF]
Experimental Gerontology, 2003 Calorie restriction (CR) extends lifespan and reduces the incidence and age of onset of age-related disease in several animal models. To determine if this nutritional intervention has similar actions in a long-lived primate species, the National Institute on Aging (NIA) initiated a study in 1987 to investigate the effects of a 30% CR in male and female
Julie A, Mattison +3 more
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The effect of high-intensity interval training with caloric restriction on gene expression of apoptosis indices HSP70 and HSP60 in the myocardium of male rats [PDF]
Journal of Shahrekord University of Medical SciencesBackground and aims: The purpose of this study was to investigate the effect of high-intensity interval training combined with calorie restriction on the expression of HSP70 and HSP60 in the myocardium of male rats.
Mohammad Mazhari +2 more
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Sirtuins and calorie restriction [PDF]
Nature Reviews Molecular Cell Biology, 2012 Studies in mice have indicated that sirtuins do have a role in mediating the effects of CR.
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, 2019 Calorie restriction is the most effective intervention with prolongevity effects in many of the organisms. Calorie restriction can be considered as the reduction of the intake of energy without reaching malnutrition. The effect of calorie restriction is not only reserved to an extended longevity but also delays the onset and reduces the progression of ...
López-Lluch, Guillermo, Navas, Plácido
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Calorie restriction and glucose regulation [PDF]
Epilepsia, 2008 Summary Ketogenic diets (KDs) are effective treatments for epilepsy. The mechanisms of action are poorly understood. In some experimental seizure models, calorie restriction and hypoglycemia may augment the antiseizure effects of KDs. In addition, inhibiting glycolysis or diverting glucose from the glycolytic pathway inhibits seizures and possibly ...
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The Potential of Calorie Restriction and Calorie Restriction Mimetics in Delaying Aging: Focus on Experimental Models [PDF]
Nutrients, 2021 Aging is a biological process determined by multiple cellular mechanisms, such as genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication, that ultimately concur in the functional ...
Emiliana Giacomello, Luana Toniolo
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Both subcutaneous semaglutide and calorie restriction improves pancreatic cell hyperplasia and gut microbiota in high-fat diet-induced obese mice. [PDF]
Nutr Metab (Lond)Luo Y +6 more
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Asian Pacific Journal of Tropical Biomedicine, 2023 Objective: To explore the combinatorial effect of epigallocatechin-3-gallate (EGCG) and calorie restriction on activation of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor involved in the antioxidant defense system of aged ...
Rajeswari Ravindran +4 more
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