Results 51 to 60 of about 34,470 (288)
Effect of Energy Restriction on Malondialdehyde Levels in Rats
Indonesian Journal of Human Nutrition, 2023 Elevated malondialdehyde (MDA) levels indicate the occurrence of cell membrane oxidation. Calorie restriction is known to extend life expectancy. This study aims to investigate the effect of calorie restriction on MDA levels in young and old rats.
Andi millaty Halifah Dirgahayu +5 more
doaj +1 more source
Calorie restriction and sirtuins revisited [PDF]
Genes & Development, 2013 Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was proposed 13 years ago and has been challenged in the intervening years.
openaire +4 more sources
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Cell Reports, 2022 Summary: Caloric restriction is a robust intervention to increase lifespan. Giving less food (calorie restriction [CR]) or allowing free access to a diluted diet with indigestible components (calorie dilution [CD]) are two methods to impose restriction ...
Xue Liu +7 more
doaj +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Effect of lactate administration on mouse skeletal muscle under calorie restriction
Current Research in Physiology, 2021 Calorie restriction (CR) involves a reductions of calorie intake without altering the nutritional balance, and has many beneficial effects, such as improving oxidative metabolism and extending lifespan.
Takanaga Shirai +4 more
doaj +1 more source
Calorie restriction and calorie-restriction mimetics activate chaperone-mediated autophagy
Proceedings of the National Academy of SciencesChaperone-mediated autophagy (CMA) is part of the mammalian cellular proteostasis network that ensures protein quality control, maintenance of proteome homeostasis, and proteome changes required for the adaptation to stress. Loss of proteostasis is one of the hallmarks of aging. CMA decreases with age in multiple rodent tissues and human cell types.
Maryam Jafari +9 more
openaire +2 more sources
Chocolate brownies and calorie restriction: the sweetest paradox?
BMJ, 2023 Could sharing chocolate cake increase engagement with research on intermittent fasting?
Oudmaijer, C A J +4 more
openaire +2 more sources
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Calorie restriction alters mitochondrial protein acetylation [PDF]
Aging Cell, 2009 SummaryCalorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanisms underlying this adaptation are largely unknown.
Schwer, Bjoern +9 more
openaire +3 more sources