Results 121 to 130 of about 93,192 (268)

Viscosity of concentrated mRNA solutions: Implications for downstream processing

open access: yesBiotechnology Progress, EarlyView.
Abstract Messenger RNA (mRNA) therapeutics can be used to protect against infectious disease and for the treatment of cancers and genetic disorders. In order to obtain the desired therapeutic dosage, it is necessary to concentrate the mRNA to levels where the viscosity of the mRNA solutions can become significant.
Amin Javidanbardan   +3 more
wiley   +1 more source

Pharmacokinetics and Bioavailability of Tolfenamic Acid in Calves: First Evaluation of Subcutaneous Administration. [PDF]

open access: yesVet Med Sci
Corum O   +11 more
europepmc   +1 more source

A Novel Anatomical Description of the Normal Terminal Fibular Artery and the Terminal Fibular Window: Radiological Findings and Surgical Implications

open access: yesClinical Anatomy, EarlyView.
ABSTRACT A novel anatomical description and radiological finding, related to the anatomical course of the terminal fibular artery (FibA) was recently reported. In the article, the authors found the terminal FibA to change its course, from being posterior and medial to the fibula to surface anteriorly and laterally before residing below the tibiofibular
Sebastian Kirdar‐Smith   +5 more
wiley   +1 more source

Demonstration of Anaplasma marginale transmission to cattle through the intra-transstadial and by unfed larvae of Rhipicephalus microplus routes, with subsequent calculation of infection rates. [PDF]

open access: yesTrop Anim Health Prod
Heller LM   +12 more
europepmc   +1 more source

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

open access: yesChemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran   +4 more
wiley   +1 more source

Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches

open access: yesChemistry – A European Journal, EarlyView.
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal   +4 more
wiley   +1 more source

Maternal heat abatement during gestation alters growth, immunity, thermotolerance, and hepatic gene expression in beef offspring during backgrounding. [PDF]

open access: yesFront Vet Sci
Ferreira ML   +9 more
europepmc   +1 more source

Fluorogenic Sydnones for Bioorthogonal Labeling of DNA

open access: yesChemistry – A European Journal, EarlyView.
Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller   +1 more
wiley   +1 more source

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