Results 171 to 180 of about 266,269 (291)

Evaluation of high flow oxygen therapy in healthy neonatal bull calves. [PDF]

J Vet Intern Med
Hess EK, Levy N, Wang S, Taylor S, Munsterman AS, Moreira ASD.   +5 more
europepmc   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

Chemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran, Landy Gu, Krege M. Christison, Kalee Thao, Liang Xue   +4 more
wiley   +1 more source

Evaluation of bovine leukaemia virus infection control measures in Japanese Black beef cattle breeding farms: A 7-year longitudinal study based on proviral load. [PDF]

Vet Rec Open
Kajisa M, Tani C, Tani M, Li J, Ito S, Yamauchi T, Murakami H, Katamoto H, Sato R, Nakahata S.   +9 more
europepmc   +1 more source

Structural and Biological Insights Into Copper(I) Phosphane Complexes With Boron‐Phenylated Poly(3‐(CF3)Pyrazolyl)‐ and Poly(6‐(CF3)‐2‐pyridyl)‐Borates

Chemistry – A European Journal, EarlyView.
This study reports six new copper(I) complexes with unusual coordination and strong anticancer activity against a panel of human cancer cell lines derived from different solid tumors. The most active compounds outperform cisplatin, even in resistant cells, by inhibiting protein disulfide isomerase and inducing redox stress that triggers non‐apoptotic ...
Vo Quang Huy Phan, Jo’ Del Gobbo, Mukundam Vanga, Deepika V. Karade, Cristina Marzano, Valentina Gandin, Laura Rigon, Carlo Santini, Maura Pellei, H. V. Rasika Dias   +9 more
wiley   +1 more source

Influence of <i>Cryptosporidium</i> and rotavirus co-infection on infectivity in calves. [PDF]

Front Vet Sci
Murakoshi F, Itoh M, Soliman RM, Masatani T, Shibano K, Nakaya T, Kato K.   +6 more
europepmc   +1 more source

Superior Intracellular Detection of Cytokines, Transcription Factors, and Phosphoproteins by CyTOF Compared With Fluorescent Cytometry

Cytometry Part A, EarlyView.
ABSTRACT Unraveling biological complexity, such as immune subset distribution in infectious disease(s), autoimmunity, or tumor heterogeneity, requires technologies capable of single‐cell proteomic analysis such as flow cytometry. Surface phenotyping alone is often insufficient, as interrogating functional capacity is required to determine cellular ...
Michael J. Cohen, Erika L. Smith‐Mahoney, Madison Bailey, Ling Wang, Lauren J. Tracey, Laura Polanco, David King, Christina Loh, Amedeo J. Cappione III, Anna C. Belkina, Jennifer E. Snyder‐Cappione   +10 more
wiley   +1 more source

Starter feed enhances growth, antioxidant capacity, and gut microbiota in Chawula yak calves. [PDF]

Sci Rep
Qingni D, Xu P, Wang H, Li K, Liu S, Qiong D, Fouad D, Shang Z.   +7 more
europepmc   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Warming summers limit reindeer grazing, weakening herbivory pressure in the mountain tundra

Ecography, EarlyView.
Climate change is predicted to alter species interactions by exposing ecosystems to increasingly frequent and intense warm spells. In the mountain tundra, grazing by large herbivores, particularly reindeer, can limit shrub expansion and preserve Arctic plant diversity.
Marianne Stoessel, Akiko Kato, Regina Lindborg   +2 more
wiley   +1 more source