Results 251 to 260 of about 372,964 (306)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Key Factors Influencing the Adoption of CAD/CAM in the Fabrication of Indirect Dental Restorations. [PDF]

Int J Dent
Downey AKC, Bennani V, Veerasamy A.
europepmc   +1 more source

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

Does Surgical Technique Matter? A Retrospective Analysis of Five-Year Outcomes After Arthroscopic vs. Open Femoroacetabular Impingement Syndrome Correction. [PDF]

Orthop Rev (Pavia)
Ghafarian A, Wajahath M, Hodson N, Mehaidli A, North T.   +4 more
europepmc   +1 more source

Mind the gap: Adherence to denosumab dosing and cessation guidelines in Australian residential aged care

British Journal of Clinical Pharmacology, EarlyView.
This original research used medication administration data to explore adherence to treatment guidelines for the most common osteoporosis medications in long‐term residential aged care (RAC) in Australia. The paper highlights gaps in adherence to treatment guidelines that must be addressed to improve outcomes of older adults living in RAC.
Marea O'Donnell, Johanna I. Westbrook, Bayzidur Rahman, Isabelle Meulenbroeks, Nasir Wabe, Ian D. Cameron, Mark Morgan, Magdalena Z. Raban   +7 more
wiley   +1 more source

Site-selective valence isomerism as a unified electronic trigger for magnetism, chirality, and catalysis in Ni-carboxylate MOFs. [PDF]

Nat Commun
Peng JH, Zhang H, Wei Z, Cao Y, Zhang J.
europepmc   +1 more source

Clusia genomes shed light on the evolution and diversity of crassulacean acid metabolism physiotypes. [PDF]

Nat Commun
Kramml HM, Herpell JB, Priemer C, Wessely Z, Schindler F, Berger A, Kellner M, Plott S, Dohovits Á, Schmidt T, Kerpan P, Afjehi-Sadat L, Chaturvedi P, Ghatak A, Brenner M, Pierides I, Fragner L, Temsch EM, Trevisan F, Ibrahim M, Fromwald F, Bellaire A, Simakov O, Huber W, Lüttge U, Paun O, Wicke S, Weiss-Schneeweiss H, Bachmann G, Weckwerth W.   +29 more
europepmc   +1 more source

Projecting environmental improvements in mineral processing pathways: the case of cathode active material production. [PDF]

Int J Life Cycle Assess
Roy S, Vaidya K, Harvey JP, Fradette L.
europepmc   +1 more source

Differences in Self-purchased Complementary and Alternative Medicine Use and Patient-reported Satisfaction between Female-specific and Non-female-specific Cancer Patients. [PDF]

J Cancer Prev
Jang A.
europepmc   +1 more source

A lightweight Chinese-English translation model integrating compressed BERT attention and phrase discard mechanism. [PDF]

Front Neurorobot
Qi X, Bao H.
europepmc   +1 more source