Results 81 to 90 of about 6,032,088 (275)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

BOOK REVIEW: Russell E.: War and Nature. Fighting Humans and Insects with Chemicals from World War I to "Silent Spring".

European Journal of Entomology, 2002
Cambridge University Press, Cambridge, UK, 2001, 315 pp.
J. CHALUPSKÝ
doaj   +1 more source

Missions, nationalism, and the end of empire [PDF]

, 2005
Title: Missions, nationalism, and the end of empire. Missions, nationalism, and the end of empire x, 313 p.
Cole-Arnal, Oscar
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Ideas políticas e historia intelectual

Prismas, 1999
A propósito de Quentin Skinner, Reason and Rhetoric in the Philosophy of Hobbes, Cambridge, Cambridge University Press, 1996, 437 páginas, y Quentin Skinner, Liberty before Liberalism, Cambridge, Cambridge University Press, 1998, 142 páginas.
Elías José Palti
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

LING, Roger, Roman Painting. Cambridge: Cambridge University Press, 1991.

Classica, Revista Brasileira de Estudos Clássicos, 1993
LING, Roger, Roman Painting. Cambridge: Cambridge University Press, 1991.
Pedro Paulo Abreu Funari
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

The Question of Space as a Challenge to Urban Studies

Ennen ja Nyt: Historian Tietosanomat, 2002
The Cambridge Urban History of Britain. Volume II: 1540–1840.
Marjo Kaartinen
doaj  

Epidemiology and Culture

RECIIS, 2015
Cambridge, Cambridge University Press, 2005 ISBN: 978-052179389 ...
Marina D. Cardoso
doaj   +1 more source