Results 31 to 40 of about 8,148 (229)

Camelid immunoglobulins and nanobody technology [PDF]

Veterinary Immunology and Immunopathology, 2009
It is well established that all camelids have unique antibodies circulating in their blood. Unlike antibodies from other species, these special antibodies are devoid of light chains and are composed of a heavy-chain homodimer. These so-called heavy-chain antibodies (HCAbs) are expressed after a V-D-J rearrangement and require dedicated constant gamma ...
Muyldermans, S, Baral, TN, Retarnozzo, VC, De Baetselier, P, De Genst, E, Kinne, J, Leonhardt, H, Magez, Stefan, Nguyen, VK, Revets, H, Rothbauer, U, Stijemans, B, Tillib, S, Wernery, U, Wyns, L, Hassanzadeh-Ghassabeh, G, Saerens, D   +16 more
openaire   +5 more sources

The Prevalence of Tail Alterations on German Dairy Farms

Animals
This study aimed to determine herd prevalence of tail alterations (deviated and shortened tails) on farms in Germany. In total, 86,355 cows on 765 dairy farms in three regions (North, South, East) were assessed for presence or absence of deviated and ...
Rieke Claussen, Roswitha Merle, Marina Volland, Stephanie Magnus, Kerstin-Elisabeth Müller   +4 more
doaj   +1 more source

A one welfare perspective on calf health: a qualitative study of knowledge, attitudes, working conditions, working atmosphere, and communication among farmers and calf-care teams on large Saxon dairy farms

Frontiers in Veterinary Science
Knowledge, attitudes, and working conditions of personnel may influence the health and welfare of animals under their care. Within a One Welfare framework, this qualitative study explored these factors on nine large dairy farms in Saxony, Germany ...
Marieke Douay--Ryckelynck, Marieke Douay--Ryckelynck, Patricia Retzler, Kim K. Meier, Roswitha Merle, Kerstin-Elisabeth Müller, Annegret Stock, Katharina Charlotte Jensen   +7 more
doaj   +1 more source

Microsatellite-Based Genetic Diversity and Population Structure of Huacaya Alpacas (Vicugna pacos) in Southern Peru

Animals, 2023
The alpaca population mostly consists of the Huacaya phenotype and is widely distributed in Southern Peru. This study aimed to estimate the genetic diversity and population structure of two Huacaya alpaca populations (Ajoyani and Quimsachata) using ...
Deyanira Figueroa, Flor-Anita Corredor, Ruben H. Mamani-Cato, Roberto F. Gallegos-Acero, Nicoll Condori-Rojas, Richard Estrada, Lizeth Heredia, Wilian Salazar, Carlos Quilcate, Carlos I. Arbizu   +9 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Past and Recent Effects of Livestock Activity on the Genetic Diversity and Population Structure of Native Guanaco Populations of Arid Patagonia

Animals, 2021
Extensive livestock production and urbanization entail modifications of natural landscapes, including installation of fences, development of agriculture, urbanization of natural areas, and construction of roads and infrastructure that, together, impact ...
Andrés Mesas, Ricardo Baldi, Benito A. González, Virginia Burgi, Alexandra Chávez, Warren E. Johnson, Juan C. Marín   +6 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Management of Dystocia in Camelids

, 2008
Dystocia is the most common emergency in camelid practice. The aim of the present paper is to review the most important clinical features of normal parturition and to discuss obstetrical situations in camelids and their non-surgical and surgical ...
Walker, P., Anouassi, A., Tibary, A., Rodriguez, J. S.   +3 more
core   +1 more source

A cross-regional examination of camelid herding practices in Peru from 900 BCE to 1450 CE: Insights from stable isotopes in camelid bone collagen and fiber.

PLoS ONE
The economic, socio-political, and cultural significance of camelids in the Andean region is well-recognized, yet an understanding of their management evolution over pre-historical periods remains limited.
Sarah J Noe, Weston C McCool, Kurt M Wilson   +2 more
doaj   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source