Results 41 to 50 of about 14,582 (241)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Enhanced antiviral immunity and dampened inflammation in llama lymph nodes upon MERS-CoV sensing: bridging innate and adaptive cellular immune responses in camelid reservoirs

Frontiers in Immunology, 2023
Middle East respiratory syndrome coronavirus (MERS-CoV) infection can cause fatal pulmonary inflammatory disease in humans. Contrarily, camelids and bats are the main reservoir hosts, tolerant for MERS-CoV replication without suffering clinical disease ...
Jordi Rodon, Jordi Rodon, Nigeer Te, Nigeer Te, Joaquim Segalés, Joaquim Segalés, Júlia Vergara-Alert, Júlia Vergara-Alert, Albert Bensaid, Albert Bensaid   +9 more
doaj   +1 more source

Serological Survey of Antibodies to Mannheimia haemolytica and Pasteurella multocida in Camelids from Argentina [PDF]

, 2017
South American camelids are a source of livestock wealth in Andean countries. In Argentina,there is little information about camelid pathogens, and most of the literature data available areseroprevalence works against virus.
Calcagno, M. L., Canellada, Andrea Mercedes, Castro, Marisa Silvia, Díaz, Ailén Magalí, Ledesma, Martin Manuel, Leoni, Juliana, Manghi, Marcela Alejandra   +6 more
core  

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Haemotrophic mycoplasmas in South American camelids in Switzerland [PDF]

, 2007
The red blood cell parasite 'Candidatus Mycoplasma haemolamae', formerly Eperythrozoon, is known to be widespread in South American camelids in the USA, causing anaemia in affected animals.
Hofmann-Lehmann, Regina, Kaufmann, C, Lutz, Hans, Meli, Marina L, Robert, N, Wengi, Nicole, Willi, Barbara, Zanolari, P   +7 more
core   +1 more source

RBD‐SD1 Nanoparticle Vaccines From DPP4‐Using Merbecoviruses Elicit a Cross‐Reactive Antibody Response but Limited Cross‐Protective Immunity

Biotechnology and Bioengineering, EarlyView.
SpyCatcher‐mi3 nanoparticles displaying RBD‐SD1 from MERS‐CoV, NL140422, and HKU4 elicited robust and cross‐reactive IgG responses in mice. Only MERS‐CoV RBD‐SD1 induced neutralizing antibodies against MERS‐CoV and protected human DPP4 mice from a MERS‐CoV challenge, indicating conserved serologic but limited cross‐neutralizing epitopes.
Peter J. Halfmann, Jeong Soo Lee, Tong Wang, Augustine Duffy, Janie E. Rogers, Natasha Chen, Elizabeth Frimpong, Carmen Rai, Yoshihiro Kawaoka, Ravi S. Kane   +9 more
wiley   +1 more source

Large-Scale Embryo Transfer Operation in Dromedary Camels: Retrospective Analysis of the Association Between Key Clinical Factors and the 2-Month Pregnancy Rate

Animals
ET is used in camel reproduction to increase the reproductive potential of elite females selected for production and show. This retrospective study analyzed the association between factors related to embryo flushing (flushing fluid turbidity and debris),
Taher Kamal Osman, Sayed Taha Ismail, Hossam R. El-Sherbiny   +2 more
doaj   +1 more source

Udder typology of Arabian dairy camels and proposal of a linear scoring system for assessing their udder traits for machine milking [PDF]

, 2015
A total of 146 multiparous lactating Arabian camels at mid lactation, machine milked twice-daily and managed under intensive conditions were used to study the morphological traits of the udder for on-field udder evaluation. Pictures from the left side of
Aljumaah, Riyadh Saleh, Ayadi, Moez, Caja, Gerardo, Faye, Bernard, Samara, Emad Mohammed   +4 more
core  

Evolution and Biogeography of Haemonchus contortus: Linking Faunal Dynamics in Space and Time [PDF]

, 2016
History is the foundation that informs about the nuances of faunal assembly that are essential in understanding the dynamic nature of the host-parasite interface.
Achi, Agosta, Agosta, Araujo, Balter, Beck, Besier, Boomker, Boomker, Brooks, Brooks, Brooks, Brooks, Brooks, Brooks, Brooks, Budischak, Capinha, Caramelli, Cerutti, Chaudhry, Chessa, Combes, Crofton, Dobson, Durette-Desset, Durette-Desset, Elton, Erwin, Fenton, Fenton, Galbreath, Gatesy, Gibbons, Giudici, Grubb, Halas, Hanotte, Harvell, Hassanin, Haydon, Hernández Fernández, Hoberg, Hoberg, Hoberg, Hoberg, Hoberg, Hoberg, Hoberg, Hoberg, Hoberg, Hoberg, Hoberg, Hoberg, Hoberg, Hoberg, Hoberg, Holt, Hulme, Hunt, IPCC, IPCC, Jacquiet, Jacquiet, Jacquiet, Janz, Janzen, Klassen, Leignel, Lichtenfels, Lichtenfels, Lichtenfels, Lichtenfels, Loftus, Mas Coma, Morrison, O'Connor, Poulin, Poulin, Prestwood, Rose, Rosenthal, Thompson, Thompson, Troell, Troell, van Dijk, van Dijk, Vrba, Vrba, Vrba, Walker, Waller, Wang, Wilson, Zarlenga, Zarlenga   +96 more
core   +2 more sources

Humans are not unique: difficult birth is common in placental mammals

Biological Reviews, EarlyView.
ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley   +1 more source