Results 61 to 70 of about 4,888 (191)

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Delving into the innate and adaptive immunity of camelids: a paradigm of interspecies adaptation and evolutionary innovation

Frontiers in Immunology
Camelids have evolved to survive some of the most challenging climatic conditions on our planet and are resilient to physiological stress such as temperature extremes, drought, storms, intense ultraviolet radiation, dehydration, and starvation.
Remya PG Ramesh, Remya PG Ramesh, Avinash Premraj, Hadida Yasmin, Hind Alkaabi, Solaf Dodan, Maitha Almahri, Noura Alameri, Yaser Y. Alyaarbi, Khaja Mohteshamuddin, Ahmed Al Aiyan, Andrew J. T. George, Walter Conca, Walter Conca, Uday Kishore, Uday Kishore   +15 more
doaj   +1 more source

Incorporating the Competencies of Evidence‐Based Veterinary Medicine Focused on Pharmacotherapeutics Into Clinical Rotations for Small Animal Dermatology and Food Animal Medicine and Surgery at a Veterinary Medical Teaching Hospital in the US

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Building the skills and knowledge necessary to practice evidence‐based veterinary medicine (EBVM) should occur throughout the veterinary curriculum. Operationalizing EBVM includes asking a clinical question in PICO format, searching the biomedical literature for evidence, critically appraising the evidence, and applying the evidence to make a ...
Virginia R. Fajt, Adam P. Patterson, Dusty Nagy, Jennifer Schleining, Kevin Washburn   +4 more
wiley   +1 more source

Occurrence and distribution of sarcoptic mange in wild Neotropical canids

Medical and Veterinary Entomology, EarlyView.
Sarcoptic mange affects most Neotropical canid species across multiple countries. It represents a widespread yet largely overlooked conservation threat with potential for cross‐species transmission. Coordinated monitoring and management efforts are needed to understand and mitigate its impacts. Abstract Sarcoptic mange, a contagious skin disease caused
Luan de Jesus Matos de Brito, Guilherme S. T. Garbino   +1 more
wiley   +1 more source

Optimization of antibody binding by adjusting thermodynamic stability during the maturation of antibody affinities

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Somatic mutations and antibody clone selection occur in B‐cell hyper‐evolution over extremely brief periods of time. Herein, we developed a technique for antibody screening by immunizing alpacas with antigens and observing antibody sequence transitions over time, a method we named Tracking the Evolution of Antibodies over time.
Yoko Akazawa‐Ogawa, Tomonari Matsuda, Norihiko Kiyose, Nobuo Miyazaki, Tetsuo Fukuta, Motoyasu Adachi, Yuji Ito, Yoshihisa Hagihara   +7 more
wiley   +1 more source

Comparative FISH-Mapping of MC1R, ASIP, and TYRP1 in New and Old World Camelids and Association Analysis With Coat Color Phenotypes in the Dromedary (Camelus dromedarius)

Frontiers in Genetics, 2019
Melanocortin 1 receptor (MC1R), the agouti signaling protein (ASIP), and tyrosinase related protein 1 (TYRP1) are among the major regulators of pigmentation in mammals.
Fahad Alshanbari, Caitlin Castaneda, Rytis Juras, Andrew Hillhouse, Mayra N. Mendoza, Gustavo A. Gutiérrez, Federico Abel Ponce de León, Terje Raudsepp   +7 more
doaj   +1 more source

AVIDbase: A biologically accurate structural dataset of nanobody‐antigen complexes

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Accurate structural data in a standardized format is one of the key factors behind the success of machine learning (ML)‐based methods for protein design and structure prediction. However, their application to nanobody‐antigen complexes has lower success rates compared to globular protein complexes, partly due to the limited amount of high ...
Tadej Medved, Jurij Lah, Goran Miličić, San Hadži   +3 more
wiley   +1 more source

The influence of sex, age and season on the haematological profile of alpacas (Vicugna pacos) in Central Europe

Veterinární Medicína, 2015
The aim of this study was to establish reference intervals for the haematological profile of alpacas on the basis of a large population of clinically healthy animals, and to determine the influence of sex, age and season on these indicators.
T. Husakova, L. Pavlata, A. Pechova, L. Tichy, K. Hauptmanova   +4 more
doaj   +1 more source

Comparative functional morphological study of the tarsal joint mobility in artiodactyls and perissodactyls in light of astragalar morphological differences

Journal of Anatomy, Volume 249, Issue 3, Page 587-603, September 2026.
This study investigated how variations in the shape of the astragalus affect tarsal joint behavior, using CT scans. In artiodactyls with a double‐pulley astragalus, the calcaneus shifted plantarly during plantarflexion. This suggests the movement increases hindlimb functional length and contributes to enhanced running speed.
Sei‐ichiro Takeda, Yoichi Masuda, Truong Son Nguyen, Hideki Endo   +3 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, Volume 16, Issue 8, Page 1459-1476, August 2026.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source