Results 181 to 190 of about 51,149 (268)

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, Volume 117, Issue 5, Page 1333-1345, May 2026.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

Exploring the Therapeutic Potential and Mechanism of Qiangzhi Fang in a Rat Model of Tic Disorder with ADHD: Behavioral and Molecular Insights. [PDF]

Neuropsychiatr Dis Treat
Lu T, Hu D, Jiang Y, Yan Z.
europepmc   +1 more source

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment

Orthopaedic Surgery, Volume 18, Issue 5, Page 897-914, May 2026.
As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li, Chaoqun Feng, Haoyun Huang, Junwen Deng, Fei Yang, Rigao Chen   +5 more
wiley   +1 more source

The treatment of myocardial ischemia-reperfusion injury: potential roles of natural drug modulating CaMKII. [PDF]

Front Pharmacol
Yang K, Zhang P, Hui X, Liu C, Li J, Liu Y.   +5 more
europepmc   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, Volume 604, Issue 9, Page 3672-3693, 1 May 2026.
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

Selective Ca_v1.3 inhibition promotes survival of transplanted dopaminergic neurons via the CaMKII-p65-p53 pathway. [PDF]

Stem Cell Reports
Tang Q, Sun J, Xue J, Qiu C, Wang T, Matveeva T, Wu Y, Li X, Cheng T, Seo H, Li M, Ma S, Schweitzer JS, Song B.   +13 more
europepmc   +1 more source

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity

The Journal of Physiology, Volume 604, Issue 10, Page 3934-3963, 15 May 2026.
Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Ben‐Adiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Monica Di Luca, Fabrizio Gardoni, Pierre J. Magistretti   +13 more
wiley   +1 more source

Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice. [PDF]

iScience
Canela M, Adell JB, Coll DR, González-Parra JA, Pinho JS, Busquets-García A.   +5 more
europepmc   +1 more source

RIPK3 inhibitor GSK872 targets angiotensin II induced cardiomyocyte hypertrophy by regulating Ca2+/ calmodulin dependent protein kinase II. [PDF]

PLoS One
Zhang J, Yu H, Yang Y, Liu A, Wang P.
europepmc   +1 more source

The role of stress hyperglycemia in in-hospital new-onset atrial fibrillation among patients with acute myocardial infarction: a narrative review. [PDF]

Front Cardiovasc Med
Wei X, Sun Y.
europepmc   +1 more source