Results 111 to 120 of about 1,724,681 (307)
Advanced Science, EarlyView.Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li +11 more
wiley +1 more source
, 2015 Intimate partners coerce thousands of women in the United States into pregnancy each year through manipulation, threats of violence, or acts that deliberately interfere with the use of, or access to, contraception or abortion.
Camp, A. Rachel
core +2 more sources
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Diasporas: Circulations, Migrations, HistoireBy examining the IRO’s rehabilitation program for DPs with disabilities, this article addresses the question of how rehabilitation was organised and understood by international institutions after the Second World War.
Johannes Glack
doaj +1 more source
Modelling practical certainty and its link with classical propositional logic [PDF]
, 2013 We model practical certainty in the language of accept & reject statement-based uncertainty models. We present three different ways, each time using a different nature of assessment: we study coherent models following from (i) favourability assessments, (
De Cooman, Gert, Van Camp, Arthur
core +1 more source
Advanced Science, EarlyView.4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang +7 more
wiley +1 more source
Advanced Science, EarlyView.Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu +10 more
wiley +1 more source
Arte y Políticas de Identidad, 2009 La mayoría de los estudios sobre el fenómeno drag king coinciden en señalar el componente subversivo de sus actos simplemente porque las performances de la masculinidad que realizan las drag kings desplazan la noción de masculinidad del sexo biológico ...
Maite Escudero Alías
doaj