Results 141 to 150 of about 549,497 (314)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Related Dictyostelium G protein subunits Gα1 and Gα2 have different roles in chemotaxis and transcription factor regulation. [PDF]

BMC Mol Cell Biol
Kiger NM, Mason NW, Rafid MI, Hadwiger JA.   +3 more
europepmc   +1 more source

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, EarlyView.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

The master virulence regulator PhoP dictates carbon metabolism by controlling cyclic AMP synthesis in Salmonella. [PDF]

PLoS Biol
Pokorzynski ND, Sams-Dodd EC, Esneault C, Jones KA, Campagna SR, Groisman EA.   +5 more
europepmc   +1 more source

Wearable Thermoelectric Generators for In Vivo Modulation of Insulin Release

Advanced Energy Materials, EarlyView.
This work presents a wearable, self‐powered thermoelectric system (IGNITE) that sustainably harvests body heat to electrically stimulate engineered human cells for insulin release. Operating autonomously without batteries, IGNITE achieves glycemic control in diabetic mice, demonstrating a significant advance in bioelectronic medicine and setting the ...
Debasis Maity, Jinbo Huang, Martin Fussenegger   +2 more
wiley   +1 more source

A Categorical ANCOVA Approach to Severity Endophenotype-Specific Genome-Wide Association Studies in Childhood Asthma. [PDF]

J Pers Med
Piparia S, Hadikhani P, Ziniti J, Hecker J, Kho AT, Sharma R, Celedón JC, McGeachie MJ, Weiss ST, Tantisira KG.   +9 more
europepmc   +1 more source

Belsen Camp [PDF]

BMJ, 1945
openaire   +2 more sources

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

Proceedings of the National Academy of Sciences of the United States of America, 2015
S. Lokireddy, N. Kukushkin, A. Goldberg
semanticscholar   +1 more source

Synergies in Agricultural Biodiversity Conservation: Decomposing the Interaction Between Nature Parks and Agri‐Environment Schemes

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Understanding how policy instruments with overlapping goals interact is crucial for leveraging their synergies. This study explores the mechanisms for regional nature parks (a form of protected areas that impose no restrictions on agriculture) to enhance the adoption of biodiversity‐conserving agri‐environment schemes (AES) in Switzerland ...
Yanbing Wang, Christian Ritzel, Antonia Kaiser, Gabriele Mack   +3 more
wiley   +1 more source

A Personal Interview With Dr. Jon C. Dalton

Journal of College Orientation, Transition, and Retention, 2010
Jeanine Ward-Roof
doaj   +1 more source