Results 21 to 30 of about 646,261 (261)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
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BMC Sports Science, Medicine and RehabilitationThe aim of this cross-sectional study was to establish age and sex-specific normative values for strength, power, agility and flexibility assessed by field-based tests in young volleyball players aged 10–18 years who were actively training and competing ...
Vladimir Grbić +4 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
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Muscle strength and power in young volleyball players: reference values and age group differences
BMC Sports Science, Medicine and RehabilitationTo date, there is a notable lack of comprehensive normative datasets that focus on youth volleyball players, which limits coaches’ and practitioners’ ability to objectively interpret individual test results, monitor longitudinal development, and ...
Vladimir Grbić +4 more
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“Beef Jerky in a Ball Gown”: The Camp Excesses of Titus Andromedon in Unbreakable Kimmy Schmidt
Open Cultural Studies, 2017 In this essay, we look at Titus Andromedon from the Netflix-sitcom Unbreakable Kimmy Schmidt (2014-) as a singular phenomenon in contemporary TV: a black queen whose use of camp distances him from stereotypes, but connects him with audiences.
Dexl Carmen, Horn Katrin
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Un automne à PinceventLe campement magdalénien du niveau IV20
Les Nouvelles de l’Archéologie, 2015 Since 1964, when the Magdalenian site of Pincevent was discovered by A. Leroi-Gourhan and his team, the methods of excavation and analysis have evolved.
Michèle Julien, Claudine Karlin
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
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Neoclassicism and Camp in Sir William Hamilton’s Naples
ABO : Interactive Journal for Women in the Arts 1640-1830, 2019 Susan Sontag, in her now-classic “Notes on Camp” (1964), traces the origins of camp to the eighteenth century (13, 14, 33). And although it is precisely the baroque and rococo art movements against which Winckelmann rebelled that Sontag identifies as ...
Ersy Contogouris
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Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
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FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
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