Results 171 to 180 of about 597,462 (243)

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +1 more source

Implementation of a Large-Scale Ebola Vaccination Campaign in Rwanda. [PDF]

Vaccines (Basel)
Ingabire R, Nyombayire J, Sayinzoga F, Mazarati JB, Mazzei A, Roey KV, Kasigazi M, Nshizirungu P, Tuganeyezu O, Nsanzimana S, Sifa C, Niyonzima J, Mirimo E, Mc Kenna P, Parker R, Tichacek A, Noben J, Wall KM, Allen S, Karita E.   +19 more
europepmc   +1 more source

Synthesis of Large‐ and Medium‐Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular SNAr

Angewandte Chemie, EarlyView.
Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani, Paritosh Dey, Nicholas H. Stillman, Daniel M. Andrade, Michal Šimek, Martin Dračínský, Daniel Bím, Paulo H. S. Paioti   +7 more
wiley   +1 more source

A Quality Improvement Campaign Reduces Head and Cervical Spine Imaging in Low-risk Trauma Patients. [PDF]

West J Emerg Med
Luke JC, Kubick RN, Sucharew HJ, Winkler K, Giles ML, Kreitzer NE, Goel AL, Thompson DO.   +7 more
europepmc   +1 more source

A Modular Synthesis of C5‐Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry

Angewandte Chemie, EarlyView.
Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy, Theo C. Webb, Barnaby W. Greenland, S. Mark Roe, John Spencer, Storm Hassell‐Hart   +5 more
wiley   +1 more source

A dataset of soil-sweep tool interaction measurements on an agricultural field including cone penetration resistance, draft force, and surface profiles under varying soil moisture conditions. [PDF]

Data Brief
Nagy D, Tamás K.
europepmc   +1 more source

Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections

Angewandte Chemie, EarlyView.
KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran, Axia Marlin, Edith K. Amason, Marie Huynh, Hannah Carlisle, Eszter Boros   +5 more
wiley   +1 more source

Pre-Post Evaluation of a Sun Safety Social Media Campaign for Young Adults to Reduce Skin Cancer Risk. [PDF]

JMIR Dermatol
Mendoza JM, Perez D, Statman MR, Price MK, Brown MF, Anwar OU, Sleiman MM, Tercyak KP.   +7 more
europepmc   +1 more source

Standardized terrestrial laser scanning dataset of forests: 3D point clouds and tree-level attributes from 121 plots across five European regions. [PDF]

Data Brief
Herrmann M, Derenthal M, Schmidt-Riese EA, Stellmes M, Janoutová R, Arendholz F, Bäte DA, Ernst J, Fakhri A, Jaki P, Katerndahl F, Kempfer F, Mansi C, Meindl J, Navrátilová B, Plewnia F, Ruhtz T, Scholl M, Waseem A, Fassnacht F.   +19 more
europepmc   +1 more source