Results 181 to 190 of about 597,462 (243)

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Spatial distribution and associated factors influencing 2024 Measles-Rubella vaccination campaign coverage among children aged 9-59 months in Mainland Tanzania: A multi-level mixed-effect analysis. [PDF]

PLoS One
Msuya HM, Lwambura S, Msuya I, Lweno O, Fakih B, Mrisho M, Tearish H, Abdallah G, Mmbaga S, Kuwawenaruwa A, Kassim M, Kassim K, Hassan F, Mdachi J, Kyesi F, Mwengee W, Mkopi A.   +16 more
europepmc   +1 more source

Impact of distribution campaigns on the use and availability of long-lasting insecticide-treated nets in rural Guinea. [PDF]

Malariaworld J
Toner E, Plato B, Johnson A, Dobson A, Jackson A, Read C, Chisholm D, Jabbie H, Barry A.   +8 more
europepmc   +1 more source

Encouraging Adults at Risk for Type 2 Diabetes to Enroll in Diabetes Prevention Programs Through a Media Campaign in Hawai'i: Cross-Sectional Study. [PDF]

JMIR Public Health Surveill
Saiki K, Lim E, Nett B, Ogawa G, Ching LK, Kawasaki RM, Barreto NA, Inoue K, Irvin LH, Kaupiko KR, Keliikoa LB, McGurk MD.   +11 more
europepmc   +1 more source

Measles epidemic in Yakusu Health Zone, Democratic Republic of Congo, 2018-2019: a retrospective observational study. [PDF]

BMC Infect Dis
Ale F, Riccio ME, Katuala Y, Maloko T, Tonamou G, Gignoux E, Ciglenecki I, Polonsky J.   +7 more
europepmc   +1 more source