Results 111 to 120 of about 276,254 (364)

cAMP Phosphodiesterase Inhibitors Increases Nitric Oxide Production by Modulating Dimethylarginine Dimethylaminohydrolases [PDF]

open access: bronze, 2011
Soni Savai Pullamsetti   +12 more
openalex   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

open access: yesAdvanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang   +6 more
wiley   +1 more source

How to Develop the Korean Camping Culture and Industry: Focused on Camping Site Selection Attributes

open access: yesSAGE Open
This study aims to promote camping as a healthy leisure culture rather than a passing trend. A literature review, expert interviews, and consultations were conducted to identify key factors influencing campers’ choice of campgrounds.
Hyungchul Joo, Yoonso Choi
doaj   +1 more source

An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm

open access: yesAdvanced Science, EarlyView.
An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han   +7 more
wiley   +1 more source

The Revitalization Concept of “Pramuka Penggalang” in The Digital Game Design [PDF]

open access: yes, 2019
The scout activity is a non-formal education in environments such as school and family. Generally, it held in the outdoors as an attractive place, challenging, creative, innovative, and fun.
Budiman, A. (Arief)   +1 more
core  

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

open access: yesAdvanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu   +10 more
wiley   +1 more source

BODY MASS INDEX AND EFFECTS DURING KAYAKING [PDF]

open access: yesSport Mont, 2012
Comparison of the results was performed among the sample of 55 male students of second year from the Faculty of Physical Education and Sports at the University of East Sarajevo, School Year 2009/2010, chronologically aged 23 years ±6 months.
Milomir Trivun   +3 more
doaj  

Induction of Specific Phosphodiesterase Isoforms by Constitutive Activation of the cAMP Pathway in Autonomous Thyroid Adenomas1 [PDF]

open access: bronze, 2000
Luca Persani   +7 more
openalex   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

open access: yesAdvanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu   +14 more
wiley   +1 more source

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