Results 61 to 70 of about 6,324 (259)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

E.P. Meinecke and the Development of the Modern Auto Campground

IdeAs, 2019
Recreational camping began in the United States in the 1860s after the conclusion of the American Civil War. It was an antimodern response to the rapid industrialization and urbanization that had begun to sweep through America. Americans embraced many of
Terence Young
doaj   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Teachers’s Attitudes towards Camping as an Extra-Curricular Activity

Inovacije u Nastavi, 2019
The modern way of life, with its technical and technological advances, is increasingly alienating man from the real primordial value of nature and its laws.
Dragan D. Martinović, Dragan S. Branković, Vladimir R. Živanović   +2 more
doaj   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Enhancing Outdoor Equipment Marketing through Augmented Reality: A Case Study of Sekaben Camp

Jurnal Sisfokom
Augmented Reality (AR) has the potential to transform product marketing by creating immersive and interactive experiences. This study presents the development of an AR-based application to enhance the marketing of outdoor equipment at Sekaben Camp, a ...
Tri Sugihartono, Rendy Rian Chrisna Putra, Irsad Dwi Sandro   +2 more
doaj   +1 more source

Itinéraire d’une plage méditerranéenne : Argelès-sur-Mer

Géographie et Cultures, 2008
La station d’Argelès-sur-Mer, réputée surtout pour ses multiples campings, bénéficie également d’une longue plage sablonneuse. Son évolution témoigne d’une attractivité durable et renouvelée par des usages multiples.
Anthony Simon
doaj   +1 more source

Reconfigurable Inflatables Through Controlled Surface Crumpling

Advanced Science, EarlyView.
ABSTRACT Inflatable structures offer remarkable versatility due to their compact storage and rapid deployment, making them ideal for lightweight, quickly assembled, and deployable applications. These structures are typically made from membranes that are nearly inextensible yet highly flexible.
Yi Yang, Hye Jun Youn, Leon Kamp, Renate Sachse, Wenjie Li, Jose Vidal, Jin Feng, Martin Bechthold, Katia Bertoldi   +8 more
wiley   +1 more source

La conferencia reimaginada. Postales, cartas y acampada juntos en lugares desnudos

Digithum, 2019
En este artículo, cinco autores proponen replantear la conferencia como una serie de postales, cartas, reglas y momentos silenciosos para que las jerarquías tradicionales del conocimiento se puedan anular, o al menos, dejar de lado.
Soile Veijola, Emily Höckert, David Carlin, Ann Light, Janne Säynäjäkangas   +4 more
doaj   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source