Anti-tumor activity of camptothecin analog conjugate of an RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer. [PDF]
Toh Y +13 more
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Self-Immolative Systems in Diagnostic and Therapeutic Applications. [PDF]
Ouédraogo WP, Cailly T, Collot V.
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Chromosome-level genome assembly of Nothapodytes nimmoniana. [PDF]
Wang J +6 more
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Potential Mechanisms of MAP Kinase JNK's Involvement in Modulating Cancer Cell Fate in a Cisplatin Concentration-Dependent Manner. [PDF]
Tenkutytė M +2 more
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Insights into Photo Degradation and Stabilization Strategies of Antibody-Drug Conjugates with Camptothecin Payloads. [PDF]
Luo S +10 more
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Prpf4 sequentially regulates the expansion and maturation of erythrocyte through distinct mechanisms. [PDF]
Deng Z +11 more
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A sphingolipid-derived paclitaxel nanovesicle for improved cancer therapy. [PDF]
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Ovatifolin Purified from <i>Leptocarpha rivularis</i> Induces Cell Death in A375 and A2058 Melanoma Cancer Cells. [PDF]
Burgos V +11 more
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Review Camptothecin: Current Perspectives
Current Medicinal Chemistry, 2006The review provides a detailed discussion of recent advances in the medicinal chemistry of camptothecin, a potent antitumor agent that targets topoisomerase I. Thousands of CPT derivatives have been synthesized. Two of them, Topotecan and Irinotecan, are commercially approved for use in clinic as antitumor agents while more are still in clinic trials ...
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