Results 91 to 100 of about 5,102,780 (337)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Examining differences in children and adolescents' exposure to food and beverage marketing in Canada by sociodemographic characteristics: Findings from the International Food Policy Study Youth Survey, 2020

, 2023
Rachel B. Acton, Mariangela Bagnato, Lauren Remedios, Monique Potvin Kent, Lana Vanderlee, Christine M. White, David Hammond   +6 more
openalex   +1 more source

Cross-cultural adaptation and validation of the Canadian Haemophilia Outcomes-Kids’ Life Assessment Tool (CHO-KLAT) in Côte d’Ivoire (the Ivory Coast) [PDF]

, 2020
Catherine Lambert, N’Dogomo Meité, Ibrahima Sanogo, Sébastien Lobet, Cédric Hermans, Séverine Henrard, Victor S. Blanchette, Nancy L. Young   +7 more
openalex   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

RELACIÓN ENTRE LAS MOTIVACIONES PARA MATRICULARSE EN EL PROGRAMA UNIVERSITARIO PARA ADULTOS MAYORES JOSÉ SARAMAGO 50+ Y LA ACTITUD HACIA LA QUÍMICA

Investigación y Postgrado, 2018
El objetivo de este trabajo fue establecer las relaciones entre la actitud hacia la química y la motivación en adultos mayores para matricularse en el curso Química para Todos y para Todo del Programa Universitario José Saramago 50+ de la Universidad de
José Antonio Murillo-Pulgarín, Armando Carrasquero-Durán, Florentina Cañada-Cañada   +2 more
doaj  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Del evento sonoro al fenómeno físico: un estudio sobre las ideas que los estudiantes mantienen sobre el sonido

Góndola, Enseñanza y Aprendizaje de las Ciencias, 2015
En el ámbito educativo se asume que las experiencias que a diario tenemos con el campo sonoro nos deben permitir comprender aquello a lo que hemos nominado como sonido, bien sea en términos ondulatorios o vibratorios.
Lina Viviana Melo Niño, Florentina Cañada Cañada, Ramiro Sánchez Baltazar   +2 more
doaj  

Physicians’ Practices for Diagnosing Liver Fibrosis in Chronic Liver Diseases: A Nationwide, Canadian Survey [PDF]

, 2014
Giada Sebastiani, Peter Ghali, Philip Wong, Marina B. Klein, Marc Deschênes, Robert P. Myers   +5 more
openalex   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source