Results 71 to 80 of about 4,735,522 (306)

“Canada will not stand idly by ...”: Ukraine in the Foreign Policy of Canada

International Studies: Interdisciplinary Political and Cultural Journal, 2016
Ukraine has always had a special place in Canadian foreign policy. Currently, Canada is deeply engaged in supporting Ukraine to restore political and economic stability and to implement democratic reforms.
Magdalena Marczuk-Karbownik
doaj   +1 more source

Canada

, 2015
Excerpt: The first Europeans to inhabit what is now Canada came from Norse countries about 1000 AD to spend at least two winters at L’Anse aux Meadows, on the northwestern tip of Newfoundland.
Badley, Ken
core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

La résistance aux antituberculeux au Canada : 2018

Canada Communicable Disease Report, 2020
Introduction : La tuberculose pharmaco-résistante est une question de santé publique d’importance mondiale constituant une menace contre les efforts entrepris pour lutter contre la tuberculose. Le Canada effectue une surveillance l’échelle nationale pour
Marie LaFreniere, Demy Dam, Réseau technique canadien de laboratoires de tuberculose, Lori Strudwick, Sarah McDermott   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

South Asian Diasporas in Canada [PDF]

, 2013
In May 2011 over 60 scholars gathered in Canada for a conference on; ‘Assessing the complexities of South Asian Migration’. This special issue of South Asian Diaspora on South Asian diasporas in Canada emerges from this event, and contains papers by ...
Walton-Roberts, Margaret
core   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Garbage consumption by Arctic terrestrial predators in one of the most pristine land areas on Earth

Polar Research
Garbage may cause substantial environmental perturbations, in part because of its consumption by wildlife. Such consumption may have direct health implications for animals and may also influence trophic relationships.
Araceli Gort-Esteve, Muzit Abrham, Christian Carøe, Johannes Måsviken, Susana Freire, Nicolas Lecomte, Patrícia Pečnerová, Anders Angerbjörn, Jordi Bartolomé Filella, Karin Norén, Fredrik Dalerum   +10 more
doaj   +1 more source