Results 31 to 40 of about 11,007 (197)

Combining Double Fluorescence In Situ Hybridization with Immunolabelling for Detection of the Expression of Three Genes in Mouse Brain Sections [PDF]

, 2016
Detection of gene expression in different types of brain cells e.g., neurons, astrocytes, oligodendrocytes, oligodendrocyte precursors and microglia, can be hampered by the lack of specific primary or secondary antibodies for immunostaining.
Fudge, A, Jolly, S, Li, H, Pringle, N, Richardson, WD   +4 more
core   +1 more source

Developing Hypoimmunogenic Human iPSC‐Derived Oligodendrocyte Progenitor Cells as an Off‐The‐Shelf Cell Therapy for Myelin Disorders

Advanced Science, 2023
Demyelinating disorders are among the most common and debilitating diseases in neurology. Canavan disease (CD) is a lethal demyelinating disease caused by mutation of the aspartoacylase (ASPA) gene, which leads to the accumulation of its substrate N ...
Lizhao Feng, Jianfei Chao, Peng Ye, Qui Luong, Guoqiang Sun, Wei Liu, Qi Cui, Sergio Flores, Natasha Jackson, Afm Nazmul Hoque Shayento, Guihua Sun, Zhenqing Liu, Weidong Hu, Yanhong Shi   +13 more
doaj   +1 more source

Long-term follow-up after gene therapy for canavan disease. [PDF]

Sci Transl Med, 2012
Leone P, Shera D, McPhee SW, Francis JS, Kolodny EH, Bilaniuk LT, Wang DJ, Assadi M, Goldfarb O, Goldman HW, Freese A, Young D, During MJ, Samulski RJ, Janson CG.   +14 more
europepmc   +2 more sources

Supporting proactive management in the context of climate change: Prioritizaing range-shifting invasive plants based on impact [PDF]

, 2020
Non-native, invasive plants are projected to shift their ranges with climate change, creating hotspots of risk where a multitude of novel species may soon establish and spread. The Northeast U.S. is one such hotspot. However, because monitoring for novel
Bradley, Bethany A, Laginhas, Brittany B., Rockwell-Postel, Mei   +2 more
core   +1 more source

Mapping the degradation pathway of a disease-linked aspartoacylase variant.

PLoS Genetics, 2021
Canavan disease is a severe progressive neurodegenerative disorder that is characterized by swelling and spongy degeneration of brain white matter.
Sarah K Gersing, Yong Wang, Martin Grønbæk-Thygesen, Caroline Kampmeyer, Lene Clausen, Martin Willemoës, Claes Andréasson, Amelie Stein, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen   +9 more
doaj   +1 more source

A rare case of a long-lived patient with Canavan syndrome

Brain Disorders
This case report describes the clinical case of a patient with Canavan Syndrome, a condition characterized by high mortality in infancy, who reached the age of 32.
Giuseppe Liardi, Salvatore Dongiovanni, Michelangelo Carucci, Valentina Andreozzi, Connye Mattera, Federica Quadro, Gennaro Calafiore, Sabrina Gentile, Nicoletta Liardi   +8 more
doaj   +1 more source

Risk factors for macro- and microvascular complications among older adults with diagnosed type 2 diabetes: findings from The Irish Longitudinal Study on Ageing [PDF]

, 2016
Objective. To explore risk factors for macro- and microvascular complications in a nationally representative sample of adults aged 50 years and over with type 2 diabetes in Ireland. Methods.
Buckley, Claire M., Canavan, Ronan J., Fitzgerald, Anthony P., Kearney, Patricia M., McHugh, Sheena M., Tracey, Marsha L.   +5 more
core   +3 more sources

Estimating the minimal cost of delivering nutrition‐specific and nutrition‐sensitive interventions in Ethiopia

Maternal &Child Nutrition, EarlyView.
The minimum cost of the 10 years on identified nutrition‐specific and nutrition‐sensitive interventions of the National Food and Nutrition Strategy in Ethiopia is estimated to be US$ 2.55bn with an average annual cost of $250 million over 10 years (2021–2030), which is only 2.3% of the Ethiopian Annual GDP 111.27 billion US dollars in 2021 (World bank).
Yetayesh Maru, Firehiwot Mesfin, Arnaud Laillou, Ramadhani Noor, Shiva Raj Adhikari, Meseret Zelalem, Hiwot Darsene, Solomon Memire, Andarge Abie, Stanley Chitekwe   +9 more
wiley   +1 more source

The bile duct ligated rat : a relevant model to study muscle mass loss in cirrhosis [PDF]

, 2016
Muscle mass loss and hepatic encephalopathy (complex neuropsychiatric disorder) are serious complications of chronic liver disease (cirrhosis) which impact negatively on clinical outcome and quality of life and increase mortality.
Bosoi, Cristina R., Bémeur, Chantal, Deutz, Nicolaas E. P., Macedo de Oliveira, Mariana, Ochoa-Sanchez, Rafael, Rose, Christopher, Ten Have, Gabriella A., Tremblay, Mélanie   +7 more
core   +1 more source

The role of MRI and MRS in the diagnosis of non hydrocephalic macrocrania in infancy and early childhood

The Egyptian Journal of Radiology and Nuclear Medicine, 2016
The aim of this study was to determine the key MRI findings in different disease causing macrocrania in early childhood that will help in early detection and diagnosis.
Dalia M. Moussa, Abdel Aziz El Nekeidy, Ahmed M. Abougabal, Tarek I. Omar, Tarek R. Saleh   +4 more
doaj   +1 more source