Results 1 to 10 of about 3,806 (190)
Comparative Analysis of Mesophilic YqfB-Type Amidohydrolases [PDF]
Biomolecules, 2022 The widespread superfamily of the human activating signal cointegrator homology (ASCH) domain was identified almost 20 years ago; however, the amount of experimental data regarding the biological function of the domain is scarce. With this study, we aimed to determine the putative cellular functions of four hypothetical ASCH domain-containing ...
Mikas Sadauskas +2 more
exaly +8 more sources
Bacterial amidohydrolases and modified 5-fluorocytidine compounds: Novel enzyme-prodrug pairs. [PDF]
PLoS One, 2023 Gene-directed enzyme prodrug therapy is an emerging strategy for cancer treatment based on the delivery of a gene that encodes an enzyme that is able to convert a prodrug into a potent cytotoxin exclusively in target cancer cells.
Preitakaitė V +6 more
europepmc +3 more sources
Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases [PDF]
PLoS ONE, 2015 Dihydropyrimidinase is a member of the cyclic amidohydrolase family, which also includes allantoinase, dihydroorotase, hydantoinase, and imidase. These metalloenzymes possess very similar active sites and may use a similar mechanism for catalysis ...
Cheng-Yang Huang
exaly +4 more sources
Response of amidohydrolases in soils to chloroform fumigation [PDF]
Journal of Plant Nutrition and Soil Science, 2002 An ongoing challenge in enzymology is the differentiation between the various pools of enzymes in soils, i.e. between accumulated (extracellular) enzymes and enzymes associated with the microbial biomass (intracellular enzymes). In order to solve this problem, 10 surface soils representing a wide range of physico-chemical properties and purified ...
M Ali Tabatabai
exaly +3 more sources
Microbial Detoxification of Ochratoxin A in Food. [PDF]
FoodsFood contamination by ochratoxin A (OTA) constitutes a significant threat to public health and global food safety and security, a challenge increasingly intensified by climate change.
Roncero E, Andrade MJ, Álvarez M.
europepmc +2 more sources
Penicillin Amidohydrolases in Fungal Autolysis [PDF]
Microbiology and Immunology, 1989 AbstractThe production of penicillin G and penicillin V amidohydrolases or acylases (E.C.3.5.1.11) was studied during the autolysis of filamentous fungi in a mineral medium, and in the same medium with phenoxyacetic acid as inducer. In all the studied fungi, enzymes showing penicillin G and penicillin V amidohydrolase activities were found.
CARLOS Alfonso
exaly +3 more sources
Structural and biophysical aspects of l-asparaginases: a growing family with amazing diversity
IUCrJ, 2021 l-Asparaginases have remained an intriguing research topic since their discovery ∼120 years ago, especially after their introduction in the 1960s as very efficient antileukemic drugs.
Joanna I. Loch, Mariusz Jaskolski
doaj +1 more source
Molecules, 2021 Dihydroorotase (DHOase), a dimetalloenzyme containing a carbamylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase (ALLase), dihydropyrimidinase (DHPase), hydantoinase, and imidase ...
Hong-Hsiang Guan +4 more
doaj +1 more source
Structure of the Ergothioneine‐Biosynthesis Amidohydrolase EgtC [PDF]
ChemBioChem, 2015 AbstractThe ubiquitous sulfur metabolite ergothioneine is biosynthesized by oxidative attachment of a sulfur atom to the imidazole ring of Nα‐trimethylhistidine. Most actinobacteria, including Mycobacterium tuberculosis, use γ‐glutamyl cysteine as a sulfur donor. In subsequent steps the carbon scaffold of γ‐glutamyl cysteine is removed by the glutamine
Vit, Allegra +3 more
openaire +5 more sources
Eclética Química, 2021 Ureases are amidohydrolases that catalyze the hydrolysis of urea to ammonia and carbamate. In addition to the enzymatic function, ureases have fungitoxic and insecticidal function, which are independent of their catalytic activity.
Elisângela Andrade Ângelo +8 more
doaj +1 more source