Results 31 to 40 of about 3,806 (190)

Structure-guided engineering of molinate hydrolase for the degradation of thiocarbamate pesticides.

PLoS ONE, 2015
Molinate is a recalcitrant thiocarbamate used to control grass weeds in rice fields. The recently described molinate hydrolase, from Gulosibacter molinativorax ON4T, plays a key role in the only known molinate degradation pathway ending in the formation ...
José P Leite, Márcia Duarte, Ana M Paiva, Frederico Ferreira-da-Silva, Pedro M Matias, Olga C Nunes, Luís Gales   +6 more
doaj   +1 more source

Combined whole-cell high-throughput functional screening for identification of new nicotinamidases/pyrazinamidases in metagenomic/polygenomic libraries

Frontiers in Microbiology, 2016
Nicotinamidases catalyze the hydrolysis of the amide bond in nicotinamide to produce ammonia and nicotinic acid. These enzymes are an essential component of the NAD+ salvage pathway and are implicated in the viability of several pathogenic organisms. Its
Rubén Zapata-Pérez, Antonio Ginés García-Saura, Mohamed Jebbar, Peter Golyshin, Álvaro Sánchez-Ferrer   +4 more
doaj   +1 more source

Identification, biochemical characterization, and subcellular localization of allantoate amidohydrolases from Arabidopsis and soybean [PDF]

, 2008
Allantoate amidohydrolases (AAHs) hydrolize the ureide allantoate to ureidoglycolate, CO(2), and two molecules of ammonium. Allantoate degradation is required to recycle purine-ring nitrogen in all plants.
Witte, Claus-Peter, Sparkes, Imogen A, Romeis, Tina, Werner, Andrea K   +3 more
core   +1 more source

Current Advances in Ochratoxin A-Degrading Enzymes [PDF]

Shipin Kexue
Ochratoxin A (OTA) poses a serious threat to human and animal health as well as the ecological environment due to its high toxicity, stable physicochemical properties, and widespread occurrence in food and feed.
NIU Zehui, LIANG Zhihong
doaj   +1 more source

Stereochemical aspects of the nucleophilic attack in different classes of l-asparaginases

IUCrJ
L-Asparaginases hydrolyze L-asparagine to L-aspartate with the release of ammonia. Currently, three completely unrelated structural classes of L-asparaginases are known, further subdivided into five types.
Miroslaw Gilski, Kinga Pokrywka, Mariusz Jaskolski   +2 more
doaj   +1 more source

Functional characterisation of bacterial histone deacetylase like amidohydrolases (HDAH) [PDF]

, 2005
Da bislang in der Literatur nur wenig über posttranslationale Modifikationen in Form von Acetylierungsmustern von Polypeptiden in Prokaryonten bekannt ist, sollte in dieser Arbeit versucht werden, Erkenntnisse ...
Hildmann, Christian
core   +1 more source

The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity [PDF]

, 2006
In eukaryotes, dihydropyrimidinase catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines.
Andersen, Birgit,, Piskur, Jure, Andersen, Birgit, Lohkamp, B, Dobritzsch, D, Lund University., Lohkamp, Bernhard, Dobritzsch, Doreen,   +7 more
core   +1 more source

Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols

Journal of Lipid Research, 2015
Ceramidases catalyze the cleavage of ceramides into sphingosine and fatty acids. Previously, we reported on the use of the RBM14 fluorogenic ceramide analogs to determine acidic ceramidase activity.
Mireia Casasampere, Luz Camacho, Francesca Cingolani, Josefina Casas, Meritxell Egido-Gabás, José Luís Abad, Carmen Bedia, Ruijuan Xu, Kai Wang, Daniel Canals, Yusuf A. Hannun, Cungui Mao, Gemma Fabrias   +12 more
doaj   +1 more source

Characterization of the metallo-dependent amidohydrolases responsible for “auxiliary” leucinyl removal in the biosynthesis of 2,2′-bipyridine antibiotics

Synthetic and Systems Biotechnology, 2017
2,2′-Bipyridine (2,2′-BiPy) is an attractive core structure present in a number of biologically active natural products, including the structurally related antibiotics caerulomycins (CAEs) and collismycins (COLs).
Ming Chen, Bo Pang, Ya-nan Du, Yi-peng Zhang, Wen Liu   +4 more
doaj   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source