Results 1 to 10 of about 5,591 (117)

Genome-Guided Identification of an OTA-Degrading Amidohydrolase AMH2102 from Acinetobacter kookii AK4 with Enhanced Soluble Expression in Escherichia coli [PDF]

Toxins
Ochratoxin A (OTA) is a globally distributed mycotoxin that poses serious threats to food safety and human health due to its nephrotoxic, hepatotoxic, and carcinogenic properties. Previous enzymatic detoxification strategies for OTA have been constrained
Zehui Niu, Shengyue Bai, Yuyun Xiao, Jingran Lai, Yuxin Jin, Zitong Zhao, Yan Yang, Shujuan Cun, Zhihong Liang   +8 more
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Structural and mechanistic insights into the divergence of pterin deaminase and sepiapterin deaminase [PDF]

Applied Microbiology and Biotechnology
Pterin deaminase and sepiapterin deaminase are key members of the amidohydrolase superfamily and play essential roles in pteridine metabolism across a wide range of biological systems.
Nivetha Shanmuganathan, Sasireka Manikandan, Jerimon Johnson, Sabaridaran Balasubramani, Angayarkanni Jayaraman, Sruthi Paleri, Theertha Ranjith, Thasleema Parveen A   +7 more
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Revisiting D‐Acylases for D‐Amino Acid Production [PDF]

Microbial Biotechnology
N‐Acyl‐D‐amino acid deacylases (EC 3.5.1.81, also known as D‐acylases) have been studied for decades for their utility in the kinetic resolution of N‐acetyl‐D,L‐amino acids (NAAs) due to a marked stereospecificity. In conjunction with an N‐succinyl‐amino
Sergio Martínez‐Rodríguez, Jose Antonio Gavira   +1 more
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The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces

Biomolecules, 2023
The activity of β-ureidopropionase, which catalyses the last step in the degradation of uracil, thymine, and analogous antimetabolites, is cooperatively regulated by the substrate and product of the reaction.
Daniela Cederfelt, Dilip Badgujar, Ayan Au Musse, Bernhard Lohkamp, U. Helena Danielson, Doreen Dobritzsch   +5 more
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Identification of a metabolic-related gene signature predicting the overall survival for patients with stomach adenocarcinoma [PDF]

PeerJ, 2021
Background The reprogramming of energy metabolism and consistently altered metabolic genes are new features of cancer, and their prognostic roles remain to be further studied in stomach adenocarcinoma (STAD).
Yuan Nie, Linxiang Liu, Qi Liu, Xuan Zhu
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Comparative Analysis of Mesophilic YqfB-Type Amidohydrolases

Biomolecules, 2022
The widespread superfamily of the human activating signal cointegrator homology (ASCH) domain was identified almost 20 years ago; however, the amount of experimental data regarding the biological function of the domain is scarce.
Roberta Statkevičiūtė, Mikas Sadauskas, Juta Rainytė, Karolina Kavaliauskaitė, Rolandas Meškys   +4 more
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Biochemical and Genetic Analysis of 4-Hydroxypyridine Catabolism in Arthrobacter sp. Strain IN13

Microorganisms, 2020
N-Heterocyclic compounds are widely spread in the biosphere, being constituents of alkaloids, cofactors, allelochemicals, and artificial substances. However, the fate of such compounds including a catabolism of hydroxylated pyridines is not yet fully ...
Justas Vaitekūnas, Renata Gasparavičiūtė, Jonita Stankevičiūtė, Gintaras Urbelis, Rolandas Meškys   +4 more
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Isoenzyme N-Acyl-l-Amino Acid Amidohydrolase NA Increases Ochratoxin A Degradation Efficacy of Stenotrophomonas sp. CW117 by Enhancing Amidohydrolase ADH3 Stability

Microbiology Spectrum, 2022
Ochratoxin A (OTA) is a potent mycotoxin mainly produced by toxicogenic strains of Aspergillus spp. and seriously contaminates foods and feedstuffs. OTA detoxification strategies are significant to food safety.
Nan Chen, Qingru Fei, Han Luo, Zemin Fang, Yazhong Xiao, Zhengjun Du, Yu Zhou   +6 more
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Heterologous Expression and Characterization of A Novel Ochratoxin A Degrading Enzyme, N-acyl-L-amino Acid Amidohydrolase, from Alcaligenes faecalis

Toxins, 2019
Ochratoxin A (OTA) is a well-known, natural contaminant in foods and feeds because of its toxic effects, such as nephrotoxicity in various animals. Recent studies have revealed that Alcaligenes faecalis could generate enzymes to efficiently degrade OTA ...
Honghai Zhang, Yunpeng Zhang, Tie Yin, Jing Wang, Xiaolin Zhang   +4 more
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Generation of an induced pluripotent stem cell line (TRNDi030-A) from a patient with Farber disease carrying a homozygous p. Y36C (c. 107 A>G) mutation in ASAH1

Stem Cell Research, 2021
Farber disease is an ultra-rare lysosomal storage disease. Mutations in the N-acylsphingosine amidohydrolase (ASAH1) gene, which encodes for the enzyme acid ceramidase (ACDase), cause ceramides to accumulate in the body.
Brianna M. Brooks, Charles D. Yeh, Jeanette Beers, Chengyu Liu, Yu-Shan Cheng, Kirill Gorshkov, Jizhong Zou, Wei Zheng, Catherine Z. Chen   +8 more
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