Results 1 to 10 of about 10,199,072 (234)

Marine-derived L-asparaginase: unlocking marine power in anti-tumor therapeutics [PDF]

Frontiers in Immunology
L-asparaginase, a critical enzyme for cancer therapy, has been primarily produced by microbes. Researches are being conducted to identify better stabilizing, low immunogenicity and highly active alternative sources has focused on marine microorganisms ...
Ritika Gopalakrishnan, Kamala Kannan, Ragul Gunasekaran, Priya Ramachandran, Dhanraj Ganapathy, Pitchiah Sivaperumal   +5 more
doaj   +2 more sources

L‒asparaginase activity in some endophytic fungi: Glutaminase‒free and low urease co‒activities. [PDF]

PLoS ONE
In this study, L‒asparaginase production in several endophytic fungi was evaluated along with their L‒glutaminase and urease co-activities. The effect of L‒asparagine and different culture media on L-asparaginase production were also evaluated. Among the
Zahra Zaeimian, Khalil-Berdi Fotouhifar, Mohsen Farzaneh   +2 more
doaj   +2 more sources

Recombinant L-asparaginase from Stenotrophomonas maltophilia: a promising low-immunogenic anticancer agent [PDF]

Microbial Cell Factories
L-asparaginase is a crucial enzyme used in chemotherapy regimens for the treatment of acute lymphoblastic leukemia (ALL), its incorporation in the pediatric treatment protocols helped in achieving a high cure rate.
Nada A. Abdelrazek, Sarra E. Saleh, Amal E. Ali, Mohammad M. Aboulwafa, Marwa M. Raafat   +4 more
doaj   +2 more sources

L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand [PDF]

Cell Death Discovery
L-asparaginase is an indispensable chemotherapeutic drug for patients with acute lymphoblastic leukemia (aLL), a life-threatening lymphoid neoplasm and the prime cause of cancer death among children.
Jung Kwon Lee, Karl Riabowol, Xidi Wang, Ki-Young Lee   +3 more
doaj   +2 more sources

Endophytic l-asparaginase-producing fungi from plants associated with anticancer properties

Journal of Advanced Research, 2015
Endophytes are novel sources of natural bioactive compounds. This study seeks endophytes that produce the anticancer enzyme l-asparaginase, to harness their potential for mass production.
Adeline Su Yien Ting
exaly   +3 more sources

Microbial L-asparaginase for Application in Acrylamide Mitigation from Food: Current Research Status and Future Perspectives

Microorganisms, 2021
L-asparaginase (E.C.3.5.1.1) hydrolyzes L-asparagine to L-aspartic acid and ammonia, which has been widely applied in the pharmaceutical and food industries.
Ruiying Jia, Xiao Wan, Xu Geng, Deming Xue, Zhenxing Xie, Chaoran Chen   +5 more
doaj   +1 more source

L-Asparaginase for the Treatment of Cancer

Ca-A Cancer Journal for Clinicians, 1973
K B Mccredie, E J Freireich, Kenneth B Mccredie   +2 more
exaly   +3 more sources

Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia. [PDF]

PLoS ONE, 2015
Although L-asparaginase related hyperglycemia is well known adverse event, it is not studied whether the profile of this adverse event is affected by intensification of L-asparaginase administration.
Hideki Yoshida, Toshihiko Imamura, Akiko M Saito, Yoshihiro Takahashi, So-ichi Suenobu, Daiichiro Hasegawa, Takao Deguchi, Yoshiko Hashii, Hirohide Kawasaki, Mikiya Endo, Hiroki Hori, Nobuhiro Suzuki, Yoshiyuki Kosaka, Koji Kato, Keiko Yumura-Yagi, Junichi Hara, Megumi Oda, Atsushi Sato, Keizo Horibe, Japan Association of Childhood Leukemia Study   +19 more
doaj   +1 more source

The nutritional and cultural conditions in shake flask culture for improved production of L-Asparaginase from endophytic fungus Fusarium sp. LCJ324: A sequential statistical method

Italian Journal of Mycology, 2023
L-Asparaginase has a greater demand due to its potential application in the food industry as well as in the pharmaceutical industry. To meet this demand, optimization of nutritional as well as physical conditions is critical for scaling up the production
Elangovan Udayan, Anbarasu Kathiravan, John Joel Gnanadoss   +2 more
doaj   +1 more source

Filamentous Fungi Producing l-Asparaginase with Low Glutaminase Activity Isolated from Brazilian Savanna Soil

Pharmaceutics, 2021
l-asparaginase is an enzyme used as treatment for acute lymphoblastic leukemia (ALL) due to its ability to hydrolyze l-asparagine, an essential amino acid synthesized by normal cells unlike neoplastic cells.
Marcela Freitas, Paula Souza, Samuel Cardoso, Kellen Cruvinel, Letícia Santos Abrunhosa, Edivaldo X. Ferreira Filho, João Inácio, Danilo Batista Pinho, Adalberto Pessoa, Pérola O. Magalhães   +9 more
doaj   +1 more source