L‒asparaginase activity in some endophytic fungi: Glutaminase‒free and low urease co‒activities. [PDF]
PLoS ONEIn this study, L‒asparaginase production in several endophytic fungi was evaluated along with their L‒glutaminase and urease co-activities. The effect of L‒asparagine and different culture media on L-asparaginase production were also evaluated. Among the
Zahra Zaeimian +2 more
doaj +2 more sources
Marine-derived L-asparaginase: unlocking marine power in anti-tumor therapeutics [PDF]
Frontiers in ImmunologyL-asparaginase, a critical enzyme for cancer therapy, has been primarily produced by microbes. Researches are being conducted to identify better stabilizing, low immunogenicity and highly active alternative sources has focused on marine microorganisms ...
Ritika Gopalakrishnan +5 more
doaj +2 more sources
Recombinant L-asparaginase from Stenotrophomonas maltophilia: a promising low-immunogenic anticancer agent [PDF]
Microbial Cell FactoriesL-asparaginase is a crucial enzyme used in chemotherapy regimens for the treatment of acute lymphoblastic leukemia (ALL), its incorporation in the pediatric treatment protocols helped in achieving a high cure rate.
Nada A. Abdelrazek +4 more
doaj +2 more sources
L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand [PDF]
Cell Death DiscoveryL-asparaginase is an indispensable chemotherapeutic drug for patients with acute lymphoblastic leukemia (aLL), a life-threatening lymphoid neoplasm and the prime cause of cancer death among children.
Jung Kwon Lee +3 more
doaj +2 more sources
Isolation and screening of l-asparaginase free of glutaminase and urease from fungal sp. [PDF]
3 Biotech, 2016 l-Asparaginase is a chemotherapeutic drug used in the treatment of acute lymphoblastic leukaemia (ALL), a malignant disorder in children. l-Asparaginase helps in removing acrylamide found in fried and baked foods that is carcinogenic in nature.
Devarai, Santhosh Kumar, Doriya, K
core +3 more sources
PKA inhibition kills l-asparaginase-resistant leukemic cells from relapsed acute lymphoblastic leukemia patients [PDF]
Cell Death DiscoveryDespite the success in treating newly diagnosed pediatric acute lymphoblastic leukemia (aLL), the long-term cure rate for the 20% of children who relapse is poor, making relapsed aLL the primary cause of cancer death in children.
Jung Kwon Lee +4 more
doaj +2 more sources
Endophytic l-asparaginase-producing fungi from plants associated with anticancer properties
Journal of Advanced Research, 2015 Endophytes are novel sources of natural bioactive compounds. This study seeks endophytes that produce the anticancer enzyme l-asparaginase, to harness their potential for mass production.
YiingYng Chow, Adeline S.Y. Ting
doaj +3 more sources
Recent advances in L-Asparaginase enzyme production and formulation development for acrylamide reduction during food processing [PDF]
Food Chemistry: XL-asparagine is an essential amino acid for cell growth and common constituent of all the proteins. During high temperature food processing it reacts with reducing sugars and leads to acrylamide production through a complex process known as Maillard ...
Arindam Jana +3 more
doaj +2 more sources
Microorganisms, 2021 L-asparaginase (E.C.3.5.1.1) hydrolyzes L-asparagine to L-aspartic acid and ammonia, which has been widely applied in the pharmaceutical and food industries.
Ruiying Jia +5 more
doaj +1 more source
L-Asparaginase for the Treatment of Cancer
Ca-A Cancer Journal for Clinicians, 1973 K B, McCredie, D H, Ho, E J, Freireich
exaly +3 more sources