Investigating the L-asparaginase Production in the Yeast Yarrowia Lipolytica [PDF]
Biological Journal of Microorganism, 2018 Introduction: L-Asparaginase catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia. This enzyme is used for the treatment of patients with acute lymphoblastic leukemia, melanosarcoma and lymphosarcoma.
Farshad Darvishi, Fereshteh Shamsi
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A Study on L-Asparaginase of Nocardia levis MK-VL_113 [PDF]
The Scientific World Journal, 2012 An enzyme-based drug, L-asparaginase, was produced by Nocardia levis MK-VL_113 isolated from laterite soils of Guntur region. Cultural parameters affecting the production of L-asparaginase by the strain were optimized.
Alapati Kavitha, Muvva Vijayalakshmi
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Production of L-asparaginase by filamentous fungi [PDF]
Memorias do Instituto Oswaldo Cruz, 2004 L-asparaginase production was investigated in the filamentous fungi Aspergillus tamarii and Aspergillus terreus. The fungi were cultivated in medium containing different nitrogen sources. A. terreus showed the highest L-asparaginase (activity) production
Maria Inez de Moura Sarquis +3 more
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Production of extracellular L- asparaginase by halophilic bacterium vibrio sp.
Biological Journal of Microorganism, 2016 Introduction: L-Asparaginase is an anti-neoplastic drug used in lymphoblastic leukemia chemotherapy. Nowadays, this enzyme derived from bacterial sources, mostly L-asparaginase II from Escherichia coli and in lesser amount L-asparaginase of Erwinia sp ...
Mahdis Zolfaghar +2 more
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Preliminary Report on Protein Preparations Exhibiting Both Asparaginase and Glutaminase Activity Purified from Rhodococcus Rhodochrous DAP 96253 [PDF]
, 2022 Bacterial L-Asparaginase has been utilized along with chemotherapy in the treatment of acute lymphoblastic leukemia. Current forms of treatment are fraught with undesirable outcomes in a significant number of cases.
Amadasun, Nosazena
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In Silico Design of a Chimeric Humanized L-asparaginase [PDF]
, 2023 Acute lymphoblastic leukemia (ALL) is the most common cancer among children worldwide, characterized by an overproduction of undifferentiated lymphoblasts in the bone marrow.
Alejandro Pedroso +8 more
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L-asparaginase: New about Well-Known Drug [PDF]
, 2021 The history of asparaginase clinical use is inextricably linked to the improvement of treatment programs for acute lymphoblastic leukaemia (ALL). Asparaginase, obtained from E.
Yuliya S. Korkina, Timur T. Valiev
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L-asparaginase Produced from Endophytes: Production, Optimization and Anticancer Activities
, 2021 L-asparaginase is an anticancer drug used to treat acute lymphoblastic leukemia. The commercial available L-asparaginase derived from bacteria has reported to induce several life-threatening side effects and irreversible complications.
Ling Sze Yap (11544211)
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A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug l-asparaginase [PDF]
, 2009 l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism.
Vaskar Saha +57 more
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L-Asparaginase from Penicillium sizovae Produced by a Recombinant Komagataella phaffii Strain
Pharmaceuticals, 2022 L-asparaginase is an important enzyme in the pharmaceutical field used as treatment for acute lymphoblastic leukemia due to its ability to hydrolyze L-asparagine, an essential amino acid synthesized by normal cells, but not by neoplastic cells.
Marcela Freitas +10 more
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