Results 11 to 20 of about 22,972 (221)

Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia. [PDF]

open access: yesPLoS ONE, 2015
Although L-asparaginase related hyperglycemia is well known adverse event, it is not studied whether the profile of this adverse event is affected by intensification of L-asparaginase administration.
Hideki Yoshida   +19 more
doaj   +1 more source

The nutritional and cultural conditions in shake flask culture for improved production of L-Asparaginase from endophytic fungus Fusarium sp. LCJ324: A sequential statistical method

open access: yesItalian Journal of Mycology, 2023
L-Asparaginase has a greater demand due to its potential application in the food industry as well as in the pharmaceutical industry. To meet this demand, optimization of nutritional as well as physical conditions is critical for scaling up the production
Elangovan Udayan   +2 more
doaj   +1 more source

Investigating the L-asparaginase Production in the Yeast Yarrowia ‎Lipolytica [PDF]

open access: yesBiological Journal of Microorganism, 2018
Introduction: L-Asparaginase catalyzes the hydrolysis of L-asparagine to L-aspartic acid and ammonia. This enzyme is used for the treatment of patients with acute lymphoblastic leukemia, melanosarcoma and lymphosarcoma.
Farshad Darvishi, Fereshteh Shamsi
doaj   +1 more source

Filamentous Fungi Producing l-Asparaginase with Low Glutaminase Activity Isolated from Brazilian Savanna Soil

open access: yesPharmaceutics, 2021
l-asparaginase is an enzyme used as treatment for acute lymphoblastic leukemia (ALL) due to its ability to hydrolyze l-asparagine, an essential amino acid synthesized by normal cells unlike neoplastic cells.
Marcela Freitas   +9 more
doaj   +1 more source

Isolasi Enzim L-Asparaginase dari Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) dan Uji Potensi terhadap Kultur Sel Leukemia Tipe K562

open access: yesJurnal Kimia Sains dan Aplikasi, 2010
Enzim L-Asparaginase merupakan enzim yang menghidrolisis L-asparagin menjadi asam L-aspartat dan amonia. L-Asparaginase dapat digunakan untuk mengobati penyakit kanker, yang bekerja dengan cara menghambat sintesis protein sel kanker tanpa merusak sel ...
Oktarina Puspitasari, Wuryanti Wuryanti
doaj   +1 more source

Solid state fermentation: An effective fermentation strategy for the production of L-asparaginase by Fusarium culmorum (ASP-87) [PDF]

open access: yes, 2017
Production of L-asparaginase by Fusarium culmorum (ASP-87) isolated from tropical soil was investigated under solid state fermentation on a laboratory scale using sixty five (65) agro based materials.
Janakiraman, S., Meghavarnam, A.K.
core   +1 more source

L-Asparaginase from Penicillium sizovae Produced by a Recombinant Komagataella phaffii Strain

open access: yesPharmaceuticals, 2022
L-asparaginase is an important enzyme in the pharmaceutical field used as treatment for acute lymphoblastic leukemia due to its ability to hydrolyze L-asparagine, an essential amino acid synthesized by normal cells, but not by neoplastic cells.
Marcela Freitas   +10 more
doaj   +1 more source

Erythrocytes as Carriers of Therapeutic Enzymes. [PDF]

open access: yes, 2020
Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to ...
Bax, BE
core   +1 more source

Cloning and Gene Expression of AnsZ Encoding L-Asparaginase Enzyme from Local Bacillus sp.

open access: yesMicrobiology Indonesia, 2014
L-asparaginase is an enzyme that catalyzes the hydrolysis of L-asparagine into L-aspartic acid and ammonia. In medical aspect, L-asparaginase especially those came from E.
RIMA AZARA   +3 more
doaj   +1 more source

A simple and efficient dye-based technique for rapid screening of fungi for L-asparaginase production [PDF]

open access: yes, 2015
Three hundred and sixty four (364) isolates of tropical soil fungi were screened for L-asparaginase production by rapid plate method using modified Czapek-Dox agar containing L-asparagine, and either bromo cresol purple or phenol red dye as an indicator.
Savitha Janakiraman, .
core   +1 more source

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