Results 41 to 50 of about 10,199,072 (234)
Arthritis &Rheumatology, Accepted Article.Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated (ACPA), anti‐carbamylated (anti‐CarP), and anti‐acetylated (AAPA) protein antibodies. In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role in early immune responses.
Aegli Athanasiadou +10 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Design, synthesis and application of fluorogenic probe for detecting l-asparaginase in serum samples
Results in Chemistry, 2021 Fluorescence-based in vitro assays are highly sensitive, selective and convenient to use, which is suitable for qualitative and quantitative detection of various types of biological samples.
Lan Wang +11 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan +8 more
wiley +1 more source
Development of a thermally stable formulation for L-asparaginase storage in aqueous conditions
, 2015 L-Asparaginase is an enzyme broadly used in pharmaceutical and food industry. Freeze-drying of L-asparaginase is time and energy consuming, and can cause enzyme activity loss.
Fu, Yankai +5 more
core +1 more source
Asian Pacific Journal of Tropical Biomedicine, 2016 Objective: To explore the anti-proliferative activity of purified l-asparaginase from Aspergillus oryzae CCT 3940 (A. oryzae). Methods: l-asparaginase was produced by submerged fermentation and purified to electrophoresis homogeneity by ionic exchanged ...
Fernanda Furlan Gonçalves Dias +3 more
doaj +1 more source
Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase
BMC Cancer, 2020 Background Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients.
Katerina Hlozkova +12 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Background By age three, 5%–75% of children have a documented antibiotic allergy (AL). Despite this prevalence, recognition remains low because of limited clinician knowledge and time. Our study evaluates a novel approach to identifying AL using electronic medical record (EMR) prescription patterns.
Georgia Koutsaplis +5 more
wiley +1 more source
Model‐Enabled Knowledge Transfer Across Cell Lines, Culture Scales and Conditions
Biotechnology and Bioengineering, EarlyView.ABSTRACT Mechanistic models are central to quantitative understanding and optimization of Chinese hamster ovary (CHO) cell culture processes, but their utility is often restricted by parameter sets calibrated for specific cell lines, scales, or operating conditions.
Luxi Yu +2 more
wiley +1 more source
Jurnal Kimia Sains dan Aplikasi, 2011 Kunyit putih (Curcuma mangga Val.) merupakan salah satu sumber L-asparaginase yang berpotensi sebagai bioaktif antikanker. Tujuan penelitian ini adalah untuk menentukan nilai LC50 dan potensi antikanker enzim L-asparaginase dari kunyit putih pada kultur ...
Citrawati Octavia Suprobo +2 more
doaj +1 more source