Results 41 to 50 of about 14,268,580 (205)

Treatment of L-Asparaginase Allergic Reaction

, 1983
The treatment of an allergic reaction to L-asparaginase is discussed in the presentation of a case of a 26-year-old man with chronic myelogenous leukemia who was undergoing methotrexate-L-asparaginase rescue therapy.
Troy H. Guthrie, A. Thomas Taylor, Terri Graves, Sandra P. Correa   +3 more
core   +1 more source

Design, synthesis and application of fluorogenic probe for detecting l-asparaginase in serum samples

Results in Chemistry, 2021
Fluorescence-based in vitro assays are highly sensitive, selective and convenient to use, which is suitable for qualitative and quantitative detection of various types of biological samples.
Lan Wang, Wenjing Qin, Ding Chen, Nanxiang Wang, Congcong Zhang, Zhijie Fang, Bin Fang, Wei Du, Naidi Yang, Qiong Wu, Bo Peng, Lin Li   +11 more
doaj   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase

BMC Cancer, 2020
Background Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients.
Katerina Hlozkova, Alena Pecinova, Natividad Alquezar-Artieda, David Pajuelo-Reguera, Marketa Simcikova, Lenka Hovorkova, Katerina Rejlova, Marketa Zaliova, Tomas Mracek, Alexandra Kolenova, Jan Stary, Jan Trka, Julia Starkova   +12 more
doaj   +1 more source

Dynamic early biomarkers predict outcomes in pediatric Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis

Pediatric Investigation, EarlyView.
This study elucidates the critical pathogenic mechanisms of pediatric Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis (EBV‐HLH), where EBV infection triggers a cytokine storm leading to immune cell hyperactivation and tissue damage. Dynamic plasma biomarkers (EBV‐DNA, ferritin, and interferon‐γ) effectively predict treatment response ...
Feifei Liu, Qing Zhang, Sitong Chen, Yunze Zhao, Dong Wang, Hongyun Lian, Honghao Ma, Tianyou Wang, Rui Zhang, Zhigang Li   +9 more
wiley   +1 more source

Purification, characterization and antiproliferative activity of l-asparaginase from Aspergillus oryzae CCT 3940 with no glutaminase activity

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To explore the anti-proliferative activity of purified l-asparaginase from Aspergillus oryzae CCT 3940 (A. oryzae). Methods: l-asparaginase was produced by submerged fermentation and purified to electrophoresis homogeneity by ionic exchanged ...
Fernanda Furlan Gonçalves Dias, Ana Lúcia Tasca Gois Ruiz, Adriana Della Torre, Helia Harumi Sato   +3 more
doaj   +1 more source

Bortezomib‐based chemotherapy in Chinese pediatric patients with relapsed/refractory acute lymphoblastic leukemia: A single‐center retrospective study

Pediatric Investigation, EarlyView.
Bortezomib‐based chemotherapy achieved an 88.9% remission rate in Chinese pediatric patients with relapsed/refractory B‐cell acute lymphoblastic leukemia, enabling 62.5% of responders to bridge to transplantation, while T‐cell acute lymphoblastic leukemia showed no response.
Xingyu Zhao, Jian Wang, Liping Que, Dunhua Zhou, Jianpei Fang, Luhong Xu   +5 more
wiley   +1 more source

Production of extracellular l-asparaginase: from bioprospecting to the engineering of an antileukemic biopharmaceutical

, 2014
L-asparaginase is an enzyme clinically accepted as an anti-tumor agent for the treatment of acute lymphoblastic leukemia and lymphosarcoma.
Oliveira, M. A., Mazzola, P. G., Monteiro, G., Farsky, S. H. P., Sette, L. D., Pessoa, A., Rangel Yagui, C. O., Carvalho, J. C. M., Magalhães, P. O., Farías, J. G. A., Motta, C. M. S., CONVERTI, ATTILIO   +11 more
core   +1 more source

Time‐Resolved Effects of Cold Atmospheric Plasma on E. coli GW‐AmxH19 Transcriptome and Proteome in an Emulated Wastewater Environment

PROTEOMICS, EarlyView.
ABSTRACT Cold atmospheric plasma (CAP) is effective against a variety of microorganisms. Here, we described effects on an Escherichia coli strain isolated from hospital wastewater caused by treatment with physical plasma. E. coli GW‐AmxH19 was incubated in artificial wastewater and treated for 15 min with CAP.
Jörg Bernhardt, Dominik Schneider, Julia Rielicke, Susanne Sievers, Veronika Hahn, Mechthild Bömeke, Anja Poehlein, Dirk Albrecht, Juergen F. Kolb, Katharina Riedel, Rolf Daniel, Daniela Zühlke   +11 more
wiley   +1 more source