Results 61 to 70 of about 13,701 (185)
European Journal of Haematology, EarlyView.ABSTRACT Thrombotic events, particularly venous thromboembolism (VTE), are a significant source of morbidity and mortality among patients with hematologic malignancies. These patients face unique challenges due to treatment‐related complications such as thrombocytopenia, coagulopathy, and heightened bleeding risk.
Mario Biglietto +12 more
wiley +1 more source
Biological Journal of Microorganism, 2016 Introduction: L- asparaginase is in an excessive demand in medical applications and in food treating industries, the request for this therapeutic enzyme is growing several folds every year.
Arastoo Badoei-dalfard +2 more
doaj
Cell Death DiscoveryL-asparaginase is a standard therapeutic option for acute lymphoblastic leukemia (aLL), a hematologic cancer that claims the most lives of pediatric cancer patients.
Jung Kwon Lee +2 more
doaj +1 more source
Journal of Paediatrics and Child Health, EarlyView.ABSTRACT Background Asparaginase is a critical component of modern multi‐agent chemotherapy regimens for paediatric acute lymphoblastic leukaemia and lymphoblastic lymphoma, with inadequate exposure leading to inferior patient outcomes. Objectives To develop a clinical practice guideline for the use of asparaginase products in the Australasian context.
Matthew J. O'Connor +15 more
wiley +1 more source
Optimization of asparaginase production from Zymomonas mobilis by continuous fermentation
Acta Scientiarum: Biological Sciences, 2016 Asparaginase is an enzyme used in clinical treatments as a chemotherapeutic agent and in food technology to prevent acrylamide formation in fried and baked foods.
Francieli Bortoluzzi Menegat +3 more
doaj +1 more source
Toxicity of Cytarabine Intravenous Constant Rate Infusion in Cats With Lymphoma
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Cytarabine intravenous constant rate infusion (IV CRI) toxicity in cats with lymphoma has not been well documented. We aimed to assess toxicities following cytarabine IV CRI as a single‐agent or within a multiagent protocol in cats with lymphoma. Medical records of cats with lymphoma treated with cytarabine IV CRI, with documented dose, route,
Rachel Hanford +5 more
wiley +1 more source
Genetic Determinants of Treatment‐Related Bone Toxicity in Pediatric Acute Lymphoblastic Leukemia
Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 786-794, September 2026.Osteonecrosis and fractures are serious corticosteroid‐induced bone toxicities in children treated for acute lymphoblastic leukemia, yet their genetic determinants remain incompletely defined. In this study, we aimed to identify novel genetic contributors to bone toxicity and to evaluate the robustness of both newly identified and previously ...
Rachid Abaji +14 more
wiley +1 more source
Association of Childhood Acute Leukemia With Autoimmune Diseases
International Journal of Cancer, Volume 159, Issue 5, Page 1188-1195, 1 September 2026.A possible link exists between various pediatric autoimmune diseases (AIDs) and increased risk of childhood leukemia. Although immune dysregulation is a key feature of these conditions, the connection between them remains unclear. In this study, using cancer registry data in Finland, the authors examined associations between AIDs and childhood acute ...
Ida Pellikka +4 more
wiley +1 more source
Postoperative Care and Management in Pediatric Hematology‐Oncology Patients
European Journal of Haematology, Volume 117, Issue 3, Page 673-681, September 2026.ABSTRACT Pediatric patients with hematologic and oncologic diseases often undergo surgical procedures as part of diagnosis and therapy. These include central venous catheter placements, tumor resections, lymph node and bone marrow biopsies, among others.
Shachi Srivatsa, Sara A. Mansfield
wiley +1 more source
Endophytic l-asparaginase-producing fungi from plants associated with anticancer properties
Journal of Advanced Research, 2015 Endophytes are novel sources of natural bioactive compounds. This study seeks endophytes that produce the anticancer enzyme l-asparaginase, to harness their potential for mass production.
YiingYng Chow, Adeline S.Y. Ting
doaj +1 more source