Results 61 to 70 of about 10,199,072 (234)

Hypersensitivity to Excipients in Drugs: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Drugs contain active pharmaceutical ingredients and excipients, compounds which enhance the pharmacokinetics, stability and palatability of the pharmaceutical formulation. While most drug hypersensitivity reactions (DHR) are caused by active ingredients, excipients may also be involved.
Lene H. Garvey, Knut Brockow, Annick Barbaud, Charlotte G. Mortz, Gianfranco Calogiuri, Asli Gelincik, Osman O. Yeğit, Alla Nakonechna, Annette Wagner, Rik Schrijvers, Toon Ieven   +10 more
wiley   +1 more source

L-asparaginase II Production by Escherichia coli [PDF]

, 1985
Growth of Escherichia coli A-l under aerobic conditions in an enriched medium with a total amount of 0.2 per cent glucose was biphasic and asparaginase II activity was detected after depletion of ammonia from the growth medium in the second phase of ...
Johnson, Terrance L. (Terrance Lewyne), 1950-
core  

In Silico Design of a Chimeric Humanized L-asparaginase

, 2023
Acute lymphoblastic leukemia (ALL) is the most common cancer among children worldwide, characterized by an overproduction of undifferentiated lymphoblasts in the bone marrow.
Alejandro Pedroso, Jorge G. Farías, Enrique Pedroso, Jorge F. Beltrán, Lisandra Herrera Belén, Rodrigo L. Castillo, Adalberto Pessoa   +6 more
core   +1 more source

Immunological responses to l-asparaginase [PDF]

Journal of Clinical Investigation, 1971
In a series of 40 patients treated with L-asparaginase for various neoplastic diseases, 6 patients had generalized anaphylactic reactions to L-asparaginase. Each of these reactors had antibodies detectable by passive hemagglutination, but precipitins were detectable in only one of this group of six patients. That patient had received two courses of the
R G, Peterson, R E, Handschumacher, M S, Mitchell   +2 more
openaire   +2 more sources

Postoperative Care and Management in Pediatric Hematology‐Oncology Patients

European Journal of Haematology, EarlyView.
ABSTRACT Pediatric patients with hematologic and oncologic diseases often undergo surgical procedures as part of diagnosis and therapy. These include central venous catheter placements, tumor resections, lymph node and bone marrow biopsies, among others.
Shachi Srivatsa, Sara A. Mansfield
wiley   +1 more source

PURIFICATION AND IMMOBILIZATION OF L-ASPARAGINASE ENZYME FROM THE THERMOPHILIC BACTERIA Bacillus licheniformis STRAIN HSA3-1a [PDF]

, 2013
L-Asparaginase gives a great benefit in the cancer treatment, especially in acute\ud lymphoblastic leukemia. L-Asparaginase is also proven to reduce the acrylamide\ud content in the foods.
Natsir, Hasnah
core  

STATISTICAL ANALYSIS OF GROWTH CONDITIONS OF NEWLY ISOLATE BACILLUS SP. PRODUCING L-ASPARAGINASE

International Islamic University Malaysia Engineering Journal, 2020
The concentrations of nutrient elements together with several physical parameters were screened to find out the significant factors for the production of L-asparaginase from newly isolated strain, Bacillus sp. from Sg Klah, Hot Spring, Perak.
Dzun Noraini Jimat, Intan Baizura Firda Mohamed, Azlin Suhaida Azmi, Azura Amid   +3 more
doaj   +1 more source

TCF/LEF family transcription factors: Molecular landscape and prognostic scoring in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
This study provides a comprehensive molecular landscape of TCF/LEF family transcription factors across 33 cancer types. We developed a TCF/LEF‐based prognostic score that correlates with immune infiltration, metabolic reprogramming and drug sensitivity, offering a robust transcriptomic signature for predicting patient survival and therapeutic response.
Zhengjun Yang, D. Q. Cai, Zhen Zhao, Zhixiang Jian, Mude Shi, Yajin Chen, Jueming Chen, Chunhua Qu, Diankui Cai   +8 more
wiley   +1 more source

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, Volume 159, Issue 2, Page 460-466, 15 July 2026.
What's new? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

Somatostatin therapy in L-asparaginase-induced pancreatitis

, 1994
L-Asparaginase-induced pancreatitis is an uncommon but potentially lethal complication. An 8-year-old girl with acute lymphoblastic leukaemia developed acute pancreatitis following treatment with asparaginase.
Y. F. Cheung, Lee, CW, K. L. Chan, Lau, YL, Yeung, CY, Cheung, YF, C. F. Chan, Chan, CF, Chan, KL, C. W. Lee, Y. L. Lau, C. Y. Yeung   +11 more
core   +1 more source