Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase
BMC Cancer, 2020 Background Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients.
Katerina Hlozkova +12 more
doaj +1 more source
Design, synthesis and application of fluorogenic probe for detecting l-asparaginase in serum samples
Results in Chemistry, 2021 Fluorescence-based in vitro assays are highly sensitive, selective and convenient to use, which is suitable for qualitative and quantitative detection of various types of biological samples.
Lan Wang +11 more
doaj +1 more source
Association of Childhood Acute Leukemia With Autoimmune Diseases
International Journal of Cancer, EarlyView.A possible link exists between various pediatric autoimmune diseases (AIDs) and increased risk of childhood leukemia. Although immune dysregulation is a key feature of these conditions, the connection between them remains unclear. In this study, using cancer registry data in Finland, the authors examined associations between AIDs and childhood acute ...
Ida Pellikka +4 more
wiley +1 more source
Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia [PDF]
, 2003 Resistance of leukemic cells to chemotherapeutic agents is associated with an unfavorable outcome in pediatric acute lymphoblastic leukemia (ALL).
Boer, M.L. (Monique) den +4 more
core +3 more sources
A Case of Cutaneous B Lymphoblastic Lymphoma With Multiple Cutaneous Tumors
JEADV Clinical Practice, EarlyView.ABSTRACT A 17‐year‐old Japanese male patient was referred to our hospital due to an erythematous tumor on part of the right mandible that had developed 3 months earlier, and similar tumors had appeared on the trunk and lower extremities. A complete blood count showed no specific abnormalities.
Tomomichi Shimizu +4 more
wiley +1 more source
Optimization of Physiological Growth Conditions for Maximal Production of L-Asparaginase by Fusarium Species [PDF]
, 2015 L-asparaginase is an enzyme which catalyzes the hydrolysis of amino acid L-asparagine to L-aspartic acid and ammonia. Due to its utility in pharmaceutical as well as food industries, there has been a paramount interest on the production of this enzyme ...
Anil kumar Meghavarnam, . +1 more
core
Metabolomics of the Tumor Microenvironment in Pediatric Acute Lymphoblastic Leukemia [PDF]
, 2013 Stefano Tiziani, Yunyi Kang, Ricky Harjanto, Joshua Axelrod, Giovanni Paternostro, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of AmericaCarlo Piermarocchi, Department of Physics and Astronomy, Michigan State ...
Axelrod, Joshua +6 more
core +3 more sources
Antithrombin: Deficiency, Diversity, and the Future of Diagnostics
Mass Spectrometry Reviews, EarlyView.ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt +2 more
wiley +1 more source
Optimization of physiological conditions for L-asparaginase production by endophytic fungi (Fusarium solani) isolated from Tinospora cordifolia (Willd.) Hook. F & Thomson [PDF]
, 2016 Asparaginase converts L-asparagine to L-aspartic acid and has received considerable attention in the recent years for its anti-carcinogenic potential. In the present investigation, the endophytic fungi isolated from T.
Fazilath Uzma, . +2 more
core
, 2011 Biomaterials are often soft materials. There is now growing interest in designing, synthesizing and characterising soft materials that mimic the properties of biological materials such as tissue, proteins, DNA or cells. Research on biomimetic soft matter
Hamley, Ian
core +1 more source