Results 31 to 40 of about 10,199,072 (234)

Effect of dose and schedule of L-asparaginase administration on early minimal residual disease in acute lymphoblastic leukemia

open access: yesIndian Journal of Medical and Paediatric Oncology, 2019
Background and Objectives: L-asparaginase has become the backbone of acute lymphoblastic leukemia induction. In Berlin–Frankfurt–Munster (BFM) 95/2000 protocols, L-asparaginase was given twice weekly for initial 4 weeks.
Satyanker Gupta   +5 more
doaj   +1 more source

Anticancer L-Asparaginase and Phytoactive Compounds From Plant Against MDR (Methicillindrug resistant) and Fungal Isolates

open access: yesDose-Response, 2022
L-asparaginase is used in chemotherapy for acute lymphoblastic leukemia and other cancers. L-asparaginase derived from bacterial source triggers immune responses.
Ambreen Aisha   +7 more
doaj   +1 more source

Production, characterization and bioinformatics analysis of l-asparaginase from a new Stenotrophomonas maltophilia EMCC2297 soil isolate

open access: yesAMB Express, 2020
An exhaustive screening program was applied for scoring a promising l-asparaginase producing-isolate. The recovered isolate was identified biochemically and molecularly and its l-asparaginase productivity was optimized experimentally and by Response ...
Nada A. Abdelrazek   +3 more
doaj   +1 more source

Characterization and Optimization of Fungal L-Asparaginase Isolated From Soil and Medicinal Plants

open access: yesJournal of Pure and Applied Microbiology, 2022
L-asparaginase is a therapeutic enzyme that converts L-asparagine into ammonia and L-aspartate. L-asparaginase is used to treat acute lymphoblastic leukaemia. In food manufacturing industries, it is used to inhibit the acrylamide formation.
S. Ranjini Priya, A. Subhashini
doaj   +1 more source

Purification, Characterization and Anticancer Activity of L-asparaginase Produced by Marine Aspergillus terreus

open access: yes, 2018
L-asparaginase (E.C.3.5.1.1) is an enzyme responsible for hydrolysis of L-asparagine into aspartic acid and ammonia, and has its significant applications in the therapeutics and food technology.
Sahar W.M. Hassan   +2 more
core   +1 more source

Bioprospecção de fungos amazônicos produtores de L- asparaginase extracelular [PDF]

open access: yes, 2020
L-asparaginase is an enzyme that plays a fundamental role in pharmaceutical and food industry. However, its greatest application has been in acute lymphoblastic leukemia (ALL) therapy.
Costa, Ana Beatriz Pereira Lelis da
core  

Synthesis and characterization of L-asparaginase encapsulated Poly-l-lysine-graft-poly(ethylene) glycol polymer nanoparticles for potential therapeutic delivery applications [PDF]

open access: yes, 2022
L-asparaginase (L-ASNase) is a therapeutic enzyme that is widely used for the treatment of hematopoietic diseases such as acute lymphoblastic leukemia and lymphomas since 1970.
NC DOCKS at Western Carolina University   +1 more
core  

Improving the production of recombinant L-Asparaginase-II in Escherichia coli by co-expressing catabolite repressor activator (cra) gene

open access: yes, 2023
Identification of a single genetic target for microbial strain improvement is difficult due to the complexity of the genetic regulatory network. Hence, a more practical approach is to identify bottlenecks in the regulatory networks that control critical ...
Debashrita Mittra (17402828)   +1 more
core   +1 more source

ACTIVITIES OF L-ASPARAGINASE FROM CICER COTYLEDONS UNDER DIFFERENT TREATMENTS [PDF]

open access: yesJournal of Plant Production, 2009
L-asparaginase (EC 3.5.1.1) activity is measured in Cicer arietinum cotyledons. Studying the relation between germination time of Cicer and L-asparaginase activity throughout 7 days revealed that L-asparaginase activity increased gradually up to the 5th ...
Laila A. U. El-Naqeeb, H. M. El-Shora
doaj   +1 more source

Preliminary study for the preparation of fatty acid bioconjugated L-asparaginase micellar nanocarrier as a delivery system for peptide anti-cancer agents [PDF]

open access: yesTrends in Pharmaceutical Sciences, 2020
In the present study, the mixing behavior of different groups of surfactants and fatty acid bioconjugated L-asparaginase investigated. The amphiphilic macromolecules were achieved by covalent linkage of fatty acids with different chain lengths (C12, C16,
Hajar Ashrafi   +4 more
doaj   +1 more source

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