Results 31 to 40 of about 13,701 (185)

NEW PRODUCTION METHOD OF BACTERIAL L-ASPRAGINASE ENZYME FROM DIFFERENT SOIL ENVIRONMENTS IN EGYPT AS ANTICANCER AGENT [PDF]

Ain Shams Medical Journal, 2022
Background: Acute lymphoblastic leukemia (ALL) is a hematologic cancer that preponderantly falls out in children betwixt 2 and 10 years of age. L-asparaginase is a constitutional element of management for long-suffering with ALL.
Mohammed Kassab
doaj   +1 more source

Skrining Bakteri Termohalofilik Penghasil L-asparaginase dari Sumber Air Panas Wawolesea Sulawesi Tenggara dan Uji Aktivitas Enzimnya

Alchemy
L-asparaginase merupakan enzim yang mengubah L-asparagin menjadi L-aspartat. L-asparagin dapat dimanfaatkan oleh sel kanker leukemia sebagai salah satu sumber nutrisinya. Penambahan L-asparaginase dapat menghambat pertumbuhan sel kanker.
Muzuni Muzuni, Jamaluddin Jamaluddin, Suriana Suriana, Ardiansyah Ardiansyah, Nur Arfa Yanti   +4 more
doaj   +1 more source

ACTIVITIES OF L-ASPARAGINASE FROM CICER COTYLEDONS UNDER DIFFERENT TREATMENTS [PDF]

Journal of Plant Production, 2009
L-asparaginase (EC 3.5.1.1) activity is measured in Cicer arietinum cotyledons. Studying the relation between germination time of Cicer and L-asparaginase activity throughout 7 days revealed that L-asparaginase activity increased gradually up to the 5th ...
Laila A. U. El-Naqeeb, H. M. El-Shora
doaj   +1 more source

Molecular docking analysis of H1 and H2 antihistamines groups with l-asparaginase II for reducing allergenicity; an in silico approach

Informatics in Medicine Unlocked, 2022
Introduction: Cancer is a pervasive disease with different types spreading widely worldwide. Acute lymphoblastic leukemia (ALL) is the bone marrow lymphocyte cancer related to the malignancy of B or T lymphoblast white blood cells.
Masoumeh Massah, Negar Balmeh, Kiomars Goodarzi, Najaf Allahyari Fard   +3 more
doaj   +1 more source

A Study on L-Asparaginase of Nocardia levis MK-VL_113

The Scientific World Journal, 2012
An enzyme-based drug, L-asparaginase, was produced by Nocardia levis MK-VL_113 isolated from laterite soils of Guntur region. Cultural parameters affecting the production of L-asparaginase by the strain were optimized.
Alapati Kavitha, Muvva Vijayalakshmi
doaj   +1 more source

Recombinant L-Asparaginase from Zymomonas mobilis: A Potential New Antileukemic Agent Produced in Escherichia coli. [PDF]

PLoS ONE, 2016
L-asparaginase is an enzyme used as a chemotherapeutic agent, mainly for treating acute lymphoblastic leukemia. In this study, the gene of L-asparaginase from Zymomonas mobilis was cloned in pET vectors, fused to a histidine tag, and had its codons ...
Karen Einsfeldt, Isis Cavalcante Baptista, Juliana Christina Castanheira Vicente Pereira, Isabele Campos Costa-Amaral, Elaine Sobral da Costa, Maria Cecília Menks Ribeiro, Marcelo Gerardin Poirot Land, Tito Lívio Moitinho Alves, Ariane Leites Larentis, Rodrigo Volcan Almeida   +9 more
doaj   +1 more source

Effect of dose and schedule of L-asparaginase administration on early minimal residual disease in acute lymphoblastic leukemia

Indian Journal of Medical and Paediatric Oncology, 2019
Background and Objectives: L-asparaginase has become the backbone of acute lymphoblastic leukemia induction. In Berlin–Frankfurt–Munster (BFM) 95/2000 protocols, L-asparaginase was given twice weekly for initial 4 weeks.
Satyanker Gupta, Amit Sehrawat, Ketan Dang, Lalit Sharma, Sarita R. Jaiswal, Suparno Chakarbarti   +5 more
doaj   +1 more source

Anticancer L-Asparaginase and Phytoactive Compounds From Plant Against MDR (Methicillindrug resistant) and Fungal Isolates

Dose-Response, 2022
L-asparaginase is used in chemotherapy for acute lymphoblastic leukemia and other cancers. L-asparaginase derived from bacterial source triggers immune responses.
Ambreen Aisha, Saba Zahra, Imtiaz M. Tahir, Asim Hussain, Naheed Bano, Alishbah Roobi, Nadia Afsheen, Yasir Saleem   +7 more
doaj   +1 more source

Characterization and Optimization of Fungal L-Asparaginase Isolated From Soil and Medicinal Plants

Journal of Pure and Applied Microbiology, 2022
L-asparaginase is a therapeutic enzyme that converts L-asparagine into ammonia and L-aspartate. L-asparaginase is used to treat acute lymphoblastic leukaemia. In food manufacturing industries, it is used to inhibit the acrylamide formation.
S. Ranjini Priya, A. Subhashini
doaj   +1 more source

Production of L-asparaginase by filamentous fungi

Memorias do Instituto Oswaldo Cruz, 2004
L-asparaginase production was investigated in the filamentous fungi Aspergillus tamarii and Aspergillus terreus. The fungi were cultivated in medium containing different nitrogen sources. A. terreus showed the highest L-asparaginase (activity) production
Maria Inez de Moura Sarquis, Edna Maria Morais Oliveira, Alberdan Silva Santos, Gisela Lara da Costa   +3 more
doaj   +1 more source