Results 31 to 40 of about 22,972 (221)

Recombinant L-Asparaginase from Zymomonas mobilis: A Potential New Antileukemic Agent Produced in Escherichia coli. [PDF]

PLoS ONE, 2016
L-asparaginase is an enzyme used as a chemotherapeutic agent, mainly for treating acute lymphoblastic leukemia. In this study, the gene of L-asparaginase from Zymomonas mobilis was cloned in pET vectors, fused to a histidine tag, and had its codons ...
Karen Einsfeldt, Isis Cavalcante Baptista, Juliana Christina Castanheira Vicente Pereira, Isabele Campos Costa-Amaral, Elaine Sobral da Costa, Maria Cecília Menks Ribeiro, Marcelo Gerardin Poirot Land, Tito Lívio Moitinho Alves, Ariane Leites Larentis, Rodrigo Volcan Almeida   +9 more
doaj   +1 more source

Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster? [PDF]

, 2019
Distinct from normal differentiated tissues, cancer cells reprogram nutrient uptake and utilization to accommodate their elevated demands for biosynthesis and energy production.
Jiang, Jie, Srivastava, Sankalp, Zhang, Ji   +2 more
core   +1 more source

Skrining Bakteri Termohalofilik Penghasil L-asparaginase dari Sumber Air Panas Wawolesea Sulawesi Tenggara dan Uji Aktivitas Enzimnya

Alchemy
L-asparaginase merupakan enzim yang mengubah L-asparagin menjadi L-aspartat. L-asparagin dapat dimanfaatkan oleh sel kanker leukemia sebagai salah satu sumber nutrisinya. Penambahan L-asparaginase dapat menghambat pertumbuhan sel kanker.
Muzuni Muzuni, Jamaluddin Jamaluddin, Suriana Suriana, Ardiansyah Ardiansyah, Nur Arfa Yanti   +4 more
doaj   +1 more source

Molecular docking analysis of H1 and H2 antihistamines groups with l-asparaginase II for reducing allergenicity; an in silico approach

Informatics in Medicine Unlocked, 2022
Introduction: Cancer is a pervasive disease with different types spreading widely worldwide. Acute lymphoblastic leukemia (ALL) is the bone marrow lymphocyte cancer related to the malignancy of B or T lymphoblast white blood cells.
Masoumeh Massah, Negar Balmeh, Kiomars Goodarzi, Najaf Allahyari Fard   +3 more
doaj   +1 more source

Structure and function of the thermostable L-asparaginase from Thermococcus kodakarensis. [PDF]

, 2017
L-Asparaginases catalyse the hydrolysis of asparagine to aspartic acid and ammonia. In addition, L-asparaginase is involved in the biosynthesis of amino acids such as lysine, methionine and threonine.
Akhtar, M, Chohan, SM, Coker, AR, Cooper, JB, Guo, J, Rashid, N, Wood, SP   +6 more
core   +1 more source

Effect of dose and schedule of L-asparaginase administration on early minimal residual disease in acute lymphoblastic leukemia

Indian Journal of Medical and Paediatric Oncology, 2019
Background and Objectives: L-asparaginase has become the backbone of acute lymphoblastic leukemia induction. In Berlin–Frankfurt–Munster (BFM) 95/2000 protocols, L-asparaginase was given twice weekly for initial 4 weeks.
Satyanker Gupta, Amit Sehrawat, Ketan Dang, Lalit Sharma, Sarita R. Jaiswal, Suparno Chakarbarti   +5 more
doaj   +1 more source

Production, characterization and bioinformatics analysis of l-asparaginase from a new Stenotrophomonas maltophilia EMCC2297 soil isolate

AMB Express, 2020
An exhaustive screening program was applied for scoring a promising l-asparaginase producing-isolate. The recovered isolate was identified biochemically and molecularly and its l-asparaginase productivity was optimized experimentally and by Response ...
Nada A. Abdelrazek, Walid F. Elkhatib, Marwa M. Raafat, Mohammad M. Aboulwafa   +3 more
doaj   +1 more source

Anticancer L-Asparaginase and Phytoactive Compounds From Plant Against MDR (Methicillindrug resistant) and Fungal Isolates

Dose-Response, 2022
L-asparaginase is used in chemotherapy for acute lymphoblastic leukemia and other cancers. L-asparaginase derived from bacterial source triggers immune responses.
Ambreen Aisha, Saba Zahra, Imtiaz M. Tahir, Asim Hussain, Naheed Bano, Alishbah Roobi, Nadia Afsheen, Yasir Saleem   +7 more
doaj   +1 more source

Glutamine Phosphoribosylpyrophosphate Amidotransferase-independent Phosphoribosyl Amine Synthesis from Ribose 5-Phosphate and Glutamine or Asparagine [PDF]

, 2007
Phosphoribosylamine (PRA) is the first intermediate in the common pathway to purines and thiamine and is generated in bacteria by glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase (EC 2.4.2.14) from PRPP and glutamine.
Downs, Diana M., Koenigsknecht, Mark J., Ramos, Itzel   +2 more
core   +2 more sources

Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]

, 2016
Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe, Barzilai, Shlomit, Escherich, Gabriele, Frandsen, Thomas Leth, Halsey, Christina, Hough, Rachael, Jeha, Sima, Kato, Motohiro, Liang, Der-Cherng, Mikkelsen, Torben Stamm, Moricke, Anja, Niinimaki, Riitta, Piette, Caroline, Putti, Maria Caterina, Raetz, Elizabeth, Schmiegelow, Kjeld, Silverman, Lewis B., Skinner, Roderick, Tuckuviene, Ruta, van der Sluis, Inge, Zapotocka, Ester   +20 more
core   +2 more sources