Jurnal Ilmiah Perikanan dan Kelautan, 2018 Enzim L-asparaginase (E.C 3.5.1.1) adalah protein tetramer yang termasuk dalam kelompok keluarga amidohydrolases homolog. ). L-asparaginase secara selektif menghidrolisis L-aspargin (L-Asn) menjadi amonia (NH3) dan asam aspartat. Penelitian ini bertujuan
Asep Awaludin Prihanto +3 more
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Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia [PDF]
, 2005 Resistance to L-asparaginase in leukemic cells may be caused by an elevated cellular expression of asparagine synthetase (AS). Previously, we reported that high AS expression did not correlate to L-asparaginase resistance in TEL-AML1 ...
Appel, I.M. (Inge) +8 more
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The potential of halophilic and halotolerant bacteria for the production of antineoplastic enzymes: L-asparaginase and L-glutaminase [PDF]
, 2016 L-asparaginase and L-glutaminase can be effectively used for the treatment of patients who suffer from accute lymphoblastic leukemia and tumor cells. Microbial sources are the best source for the bulk production of these enzymes. However, their long-term
Amoozegar, Mohammad Ali +2 more
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L-Asparaginase-Based Biosensors [PDF]
Encyclopedia, 2021 L-asparaginase (ASNase) is an aminohydrolase enzyme widely used in the pharmaceutical and food industries. Although currently its main applications are focused on the treatment of lymphoproliferative disorders such as acute lymphoblastic leukemia (ALL) and acrylamide reduction in starch-rich foods cooked at temperatures above 100 °C, its use as a ...
João C. F. Nunes +7 more
openaire +3 more sources
Growth inhibitory and proapoptotic effects of l-asparaginase from Fusarium culmorum ASP-87 on human leukemia cells (Jurkat) [PDF]
, 2017 The objective of this study was to evaluate the anticancer properties of l-asparaginase purified from fungal isolate Fusarium culmorum ASP-87 against human T-cell leukemia cell line (Jurkat).
Janakiraman, S. +3 more
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Jurnal Kimia Sains dan Aplikasi, 2008 Telah dilakukan penelitian tentang isolasi enzim L-asparaginase yang berasal dari kunyit putih (Curcuma mangga Vall) dan uji aktifitas pada leukimia tipe K562.
Agustina Arpintasari +2 more
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Isolation and identification of L-asparaginase-producing endophytic fungi from the Asteraceae family plant species of Iran [PDF]
PeerJ, 2020 L-asparaginase is an important anticancer enzyme that is used in the first line treatment of acute lymphoblastic leukemia. This study was conducted to isolate L-asparaginase-producing endophytic fungi from medicinal plants of family Asteraceae.
Sareh Hatamzadeh +6 more
doaj +2 more sources
Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan, 2019 L-asparaginase (EC 3.5.1.1) adalah enzim yang menghidrolisis asam amino L-asparagin menjadi amonia dan asam aspartat. Enzim ini mempunyai manfaat utama dalam bidang farmasi dan industri pangan.
Asep Awaludin Prihanto +2 more
doaj +1 more source
Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth [PDF]
, 2018 In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS),
Andreoli, Roberta +8 more
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A Study on L-Asparaginase of Nocardia levis MK-VL_113
The Scientific World Journal, 2012 An enzyme-based drug, L-asparaginase, was produced by Nocardia levis MK-VL_113 isolated from laterite soils of Guntur region. Cultural parameters affecting the production of L-asparaginase by the strain were optimized.
Alapati Kavitha, Muvva Vijayalakshmi
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