Understanding the Relationships between Free Asparagine in Grain and Other Traits to Breed Low-Asparagine Wheat [PDF]
Plants, 2022 Since the discovery of acrylamide in food, and the identification of free asparagine as the key determinant of acrylamide concentration in wheat products, our understanding of how grain asparagine content is regulated has improved greatly.
Nigel G. Halford +2 more
exaly +5 more sources
Wheat with greatly reduced accumulation of free asparagine in the grain, produced by CRISPR/Cas9 editing of asparagine synthetase gene TaASN2 [PDF]
Plant Biotechnology Journal, 2021 Summary Free asparagine is the precursor for acrylamide, which forms during the baking, toasting and highâtemperature processing of foods made from wheat.
Nigel G. Halford +2 more
exaly +3 more sources
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
Cell Metabolism, 2021 SUMMARY Mitochondrial respiration is critical for cell proliferation. In addition to producing ATP, respiration generates biosynthetic precursors, such as aspartate, an essential substrate for nucleotide synthesis.
Costas A Lyssiotis +2 more
exaly +2 more sources
SLC1A5 provides glutamine and asparagine necessary for bone development in mice
eLife, 2021 Osteoblast differentiation is sequentially characterized by high rates of proliferation followed by increased protein and matrix synthesis, processes that require substantial amino acid acquisition and production.
Deepika Sharma +4 more
doaj +2 more sources
Asparagine: A Metabolite to Be Targeted in Cancers
Metabolites, 2021 Amino acids play central roles in cancer progression beyond their function as building blocks for protein synthesis. Thus, targeting amino acid acquisition and utilization has been proved to be therapeutically beneficial in various pre-clinical models ...
Sandeep Batra, Ji Zhang, Jie Jiang
exaly +2 more sources
Metabolism of asparagine in the physiological state and cancer
Cell Communication and SignalingAsparagine, an important amino acid in mammals, is produced in several organs and is widely used for the production of other nutrients such as glucose, proteins, lipids, and nucleotides.
Qiong Yuan +6 more
doaj +2 more sources
As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
Cell Metabolism, 2018 Summary When mammalian cells are deprived of glutamine, exogenous asparagine rescues cell survival and growth. Here we report that this rescue results from use of asparagine in protein synthesis.
Andrew Intlekofer +2 more
exaly +2 more sources
Nature Communications, 2020 Cancer cells can produce asparagine, yet both the regulation and biological functions of asparagine are unclear. Here the authors show that p53 suppresses asparagine synthesis and disrupts asparagine-aspartate homeostasis contributing to tumor growth ...
Longfei Deng +7 more
doaj +2 more sources
Cancer Cell, 2018 Summary KRAS is a regulator of the nutrient stress response in non-small cell lung cancer (NSCLC). Induction of the ATF4 pathway during nutrient depletion requires AKT and NRF2 downstream of KRAS.
Tina Cowan, Anna Scott, Davide Ruggero
exaly +2 more sources
ASNS-dependent asparagine availability supports intestinal ILC2 responses and type 2 immunity under nutrient-limited conditions [PDF]
Frontiers in ImmunologyIntroductionNutrient availability critically governs group 2 innate lymphoid cell (ILC2) function and type 2 immunity. Here, we identify the non-essential amino acid asparagine (Asn) as a critical metabolite required for ILC2 survival and function ...
Wenyu Tian +4 more
doaj +2 more sources