Results 1 to 10 of about 101,970 (257)

Understanding the Relationships between Free Asparagine in Grain and Other Traits to Breed Low-Asparagine Wheat

Plants, 2022
Since the discovery of acrylamide in food, and the identification of free asparagine as the key determinant of acrylamide concentration in wheat products, our understanding of how grain asparagine content is regulated has improved greatly.
Joseph Oddy, Sarah Raffan, Mark D. Wilkinson, J. Stephen Elmore, Nigel G. Halford   +4 more
doaj   +3 more sources

Recharacterization of EmAGA, a Potential Candidate for Novel ALL Therapeutics [PDF]

Biomolecules
Aspartylglucosaminidase (AGA) is an amidohydrolase that can hydrolyze the amide bond between N-acetylglucosamine (GlcNAc) and asparagine (Asn), producing N-acetylglucosamine and aspartic acid (Asp).
Qiange Lin, Yuxin Zhang, Junyou Lin, Yilin Ye, Xin Qian, Xinrong Lu, Shaoxian Lyu, Xinliu Geng, Li Chen, Guiqin Sun   +9 more
doaj   +2 more sources

Asparagine Synthesis During Tobacco Leaf Curing

Plants, 2019
Senescence is a genetically controlled mechanism that modifies leaf chemistry. This involves significant changes in the accumulation of carbon- and nitrogen-containing compounds, including asparagine through the activity of asparagine synthetases.
Lucien Bovet, Cecilia Cheval, Aurore Hilfiker, James Battey, Delphine Langlet, Herve Broye, Joanne Schwaar, Pierrick Ozelley, Gerhard Lang, Nicolas Bakaher, Helene Laparra, Simon Goepfert   +11 more
doaj   +3 more sources

Targeting asparagine potentiates anti-PD-L1 immunotherapy in gastric cancer by enhancing CD8+ T cell anti-tumor response [PDF]

Frontiers in Immunology
IntroductionImmunotherapy efficacy in gastric cancer (GC) is often constrained by the tumor microenvironment (TME), which is profoundly influenced by aberrant metabolism. Asparagine, an amino acid critical for neoplastic proliferation, also modulates CD8+
Mingpai Ge, Mingpai Ge, Mingpai Ge, Longfei Wang, Longfei Wang, Bowen Zheng, Bowen Zheng, Lu Zhan, Lu Cui, Han Wang, Enyuan Huang, Yuan Xu, Xusheng Chang, Zhaorui Liu, Jun Xu, Kai Yin, Kai Yin   +16 more
doaj   +2 more sources

Aspartate Metabolism Facilitates IL-1β Production in Inflammatory Macrophages

Frontiers in Immunology, 2021
Increasing evidence support that cellular amino acid metabolism shapes the fate of immune cells; however, whether aspartate metabolism dictates macrophage function is still enigmatic.
Hao Wang, Xueyue Zheng, Bingnan Liu, Yaoyao Xia, Zhongquan Xin, Baichuan Deng, Liuqin He, Liuqin He, Jinping Deng, Wenkai Ren   +9 more
doaj   +1 more source

Assimilation of Nitrate into Asparagine for Transport in Soybeans

Agronomy, 2023
In this study, the systematic analysis of nitrate assimilation and transport in soybean roots was further improved by analyzing the concentrations of nitrate assimilates, asparagine and glutamine, in soybean roots and the related enzyme activities.
Sha Li, Xiaochen Lyu, Xuelai Wang, Shuhong Zhao, Chunmei Ma, Chao Yan, Zhenping Gong   +6 more
doaj   +1 more source

Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC cells consume large amounts of glutamine to survive, but can adapt to glutamine depletion in the presence of an exogenous asparagine.
Keiichiro Okuda, Atsushi Umemura, Seita Kataoka, Kota Yano, Aya Takahashi, Shinya Okishio, Hiroyoshi Taketani, Yuya Seko, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Hayato Nakagawa, Yu Liu, Yasuhide Mitsumoto, Yoshihiro Kanbara, Toshihide Shima, Takeshi Okanoue, Yoshito Itoh   +17 more
doaj   +1 more source

SLC1A5 provides glutamine and asparagine necessary for bone development in mice

eLife, 2021
Osteoblast differentiation is sequentially characterized by high rates of proliferation followed by increased protein and matrix synthesis, processes that require substantial amino acid acquisition and production.
Deepika Sharma, Yilin Yu, Leyao Shen, Guo-Fang Zhang, Courtney M Karner   +4 more
doaj   +1 more source

Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen

Frontiers in Immunology, 2018
The interaction between host and pathogen decidedly shapes the outcome of an infection, thus understanding this interaction is critical to the treatment of a pathogen-induced infection.
Wenkai Ren, Wenkai Ren, Ranjith Rajendran, Yuanyuan Zhao, Bie Tan, Guoyao Wu, Fuller W. Bazer, Guoqiang Zhu, Yuanyi Peng, Xiaoshan Huang, Jinping Deng, Yulong Yin   +11 more
doaj   +1 more source

Differential gene expression provides leads to environmentally regulated soybean seed protein content

Frontiers in Plant Science, 2023
Soybean is an important global source of plant-based protein. A persistent trend has been observed over the past two decades that soybeans grown in western Canada have lower seed protein content than soybeans grown in eastern Canada.
Julia C. Hooker, Julia C. Hooker, Myron Smith, Gerardo Zapata, Martin Charette, Doris Luckert, Ramona M. Mohr, Ketema A. Daba, Thomas D. Warkentin, Mehri Hadinezhad, Brent Barlow, Anfu Hou, François Lefebvre, Ashkan Golshani, Elroy R. Cober, Bahram Samanfar, Bahram Samanfar   +16 more
doaj   +1 more source