Results 21 to 30 of about 149,328 (227)

Aspartate Metabolism Facilitates IL-1β Production in Inflammatory Macrophages

Frontiers in Immunology, 2021
Increasing evidence support that cellular amino acid metabolism shapes the fate of immune cells; however, whether aspartate metabolism dictates macrophage function is still enigmatic.
Hao Wang, Xueyue Zheng, Bingnan Liu, Yaoyao Xia, Zhongquan Xin, Baichuan Deng, Liuqin He, Liuqin He, Jinping Deng, Wenkai Ren   +9 more
doaj   +1 more source

PTTG1 reprograms asparagine metabolism to promote hepatocellular carcinoma progression.

Cancer Research, 2023
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a poor prognosis. Pituitary tumor transforming gene 1 (PTTG1) is highly expressed in HCC, suggesting it could play an important role in hepatocellular carcinogenesis ...
Qi Zhou, Lei-Jia Li, Fei-Fei Sha, Yi-Ming Lei, Xuanen Tian, Ling-Jun Chen, Yan Chen, Hui-Ling Liu, Yun-Wei Guo   +8 more
semanticscholar   +1 more source

Induced mutations in ASPARAGINE SYNTHETASE-A2 reduce free asparagine concentration in the wheat grain [PDF]

, 2022
Acrylamide is a neurotoxin and probable carcinogen formed as a processing contam-inant during baking and production of different foodstuffs, including bread products.The amino acid asparagine is the limiting substrate in the Maillard reaction ...
Richard Esten Mason, Yucong Xie, Stromberger, J., Rocío Alarcón‐Reverte, John Stromberger, Xie, Y., Pearce, S., Stephen Pearce, Jennifer D. Cotter, Mason, R. E., Cotter, J. D., Alarcon-Reverte, R.   +11 more
core   +1 more source

Asparagine protects pericentral hepatocytes during acute liver injury

Journal of Clinical Investigation, 2023
The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in ...
Yu Sun, H. Demagny, Adrien Fauré, Francesca Pontanari, A. Jalil, Nadia Bresciani, Ece Yildiz, M. Korbelius, A. Perino, K. Schoonjans   +9 more
semanticscholar   +1 more source

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

Nature Cancer, 2022
The pancreatic tumor microenvironment drives deregulated nutrient availability. Accordingly, pancreatic cancer cells require metabolic adaptations to survive and proliferate.
C. Halbrook, G. Thurston, Seth Boyer, Cecily Anaraki, Jennifer A. Jiménez, Amy M. McCarthy, N. Steele, S. Kerk, H. Hong, Lin Lin, Fiona V Law, Catherine Felton, Lorenzo Scipioni, Peter Sajjakulnukit, A. Andren, A. Beutel, Rima Singh, Barbara S Nelson, F. Van den Bergh, A. Krall, P. Mullen, Li Zhang, S. Batra, J. Morton, B. Stanger, H. Christofk, M. Digman, D. Beard, Andrea Viale, Ji Zhang, H. Crawford, Marina Pasca di Magliano, Claus Jørgensen, C. Lyssiotis   +33 more
semanticscholar   +1 more source

Assimilation of Nitrate into Asparagine for Transport in Soybeans

Agronomy, 2023
In this study, the systematic analysis of nitrate assimilation and transport in soybean roots was further improved by analyzing the concentrations of nitrate assimilates, asparagine and glutamine, in soybean roots and the related enzyme activities.
Sha Li, Xiaochen Lyu, Xuelai Wang, Shuhong Zhao, Chunmei Ma, Chao Yan, Zhenping Gong   +6 more
doaj   +1 more source

Reduced free asparagine in wheat grain resulting from a natural deletion of TaASN-B2: investigating and exploiting diversity in the asparagine synthetase gene family to improve wheat quality [PDF]

, 2021
Background Understanding the determinants of free asparagine concentration in wheat grain is necessary to reduce levels of the processing contaminant acrylamide in baked and toasted wheat products.
Ravet, K., Minter, A., Mark Wilkinson, Elmore, J. S., Mead, Andrew, Pearce, S., Pearce, Stephen, Sarah Raffan, Stephen Pearce, Halford, N. G., Wilkinson, M. D., Rocío Alarcón-Reverte, Cryer, Nicholas C., Alarcon-Reverte, R., J. Stephen Elmore, Nigel G. Halford, de Almeida, Isabel Moreira, Nicholas C. Cryer, Ravet, Karl, Andrew Mead, Alarcón-Reverte, Rocío, Halford, Nigel G., Karl Ravet, Isabel Moreira de Almeida, Andrea Minter, Minter, Andrea, Oddy, Joseph, Moreira de Almeida, I., Wilkinson, Mark, Oddy, J., Elmore, J. Stephen, Mead, A., Joseph Oddy, Raffan, S., Raffan, Sarah, Cryer, N.   +35 more
core   +1 more source

Cereal asparagine synthetase genes [PDF]

, 2020
Asparagine synthetase catalyses the transfer of an amino group from glutamine to aspartate to form glutamate and asparagine. The accumulation of free (non-protein) asparagine in crops has implications for food safety because free asparagine is the ...
Sarah Raffan, Halford, N. G., Raffan, S., Nigel G. Halford   +3 more
core   +1 more source

Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC cells consume large amounts of glutamine to survive, but can adapt to glutamine depletion in the presence of an exogenous asparagine.
Keiichiro Okuda, Atsushi Umemura, Seita Kataoka, Kota Yano, Aya Takahashi, Shinya Okishio, Hiroyoshi Taketani, Yuya Seko, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Hayato Nakagawa, Yu Liu, Yasuhide Mitsumoto, Yoshihiro Kanbara, Toshihide Shima, Takeshi Okanoue, Yoshito Itoh   +17 more
doaj   +1 more source

Asparagine synthetase regulates lung-cancer metastasis by stabilizing the β-catenin complex and modulating mitochondrial response

Cell Death and Disease, 2022
The availability of asparagine is the limitation of cell growth and metastasis. Asparagine synthetase (ASNS) was an essential enzyme for endogenous asparagine products.
Dongjing Cai, Zi-Yu Zhang, Y. Bu, Li Li, Yue-Zhen Deng, Lun-Qun Sun, Cheng-Ping Hu, Min Li   +7 more
semanticscholar   +1 more source