Results 31 to 40 of about 149,328 (227)

Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression

Science Advances, 2022
Depletion of circulating asparagine with l-asparaginase (ASNase) is a mainstay of leukemia treatment and is under investigation in many cancers. Expression levels of asparagine synthetase (ASNS), which catalyzes asparagine synthesis, were considered ...
Manuel Grima-Reyes, Ashaina Vandenberghe, Ivan Nemazanyy, Pauline Meola, R. Paul, J. Reverso-Meinietti, Adriana Martinez-Turtos, Nicolas Nottet, Wai-Kin Chan, P. Lorenzi, S. Marchetti, J. Ricci, J. Chiche   +12 more
semanticscholar   +1 more source

Glutamine and asparagine activate mTORC1 independently of Rag GTPases

Journal of Biological Chemistry, 2020
Nutrient sensing by cells is crucial, and when this sensing mechanism is disturbed, human disease can occur. mTOR complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy.
Delong Meng, Qianmei Yang, Huanyu Wang, Chase H. Melick, Rishika Navlani, A. Frank, Jenna L. Jewell   +6 more
semanticscholar   +1 more source

Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation

JCI Insight, 2021
T cell receptor (TCR) triggering by antigen results in metabolic reprogramming that, in turn, facilitates the exit of T cells from quiescence. The increased nutrient requirements of activated lymphocytes are met, in part, by upregulation of cell surface ...
H. C. Hope, R. Brownlie, C. Fife, L. Steele, M. Lorger, Robert J. Salmond   +5 more
semanticscholar   +1 more source

Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia

Frontiers in Oncology, 2020
Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly regulated at the transcriptional level, being induced by both the Amino Acid ...
M. Chiu, G. Taurino, M. Bianchi, M. Kilberg, O. Bussolati   +4 more
semanticscholar   +1 more source

Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen

Frontiers in Immunology, 2018
The interaction between host and pathogen decidedly shapes the outcome of an infection, thus understanding this interaction is critical to the treatment of a pathogen-induced infection.
Wenkai Ren, Wenkai Ren, Ranjith Rajendran, Yuanyuan Zhao, Bie Tan, Guoyao Wu, Fuller W. Bazer, Guoqiang Zhu, Yuanyi Peng, Xiaoshan Huang, Jinping Deng, Yulong Yin   +11 more
doaj   +1 more source

Differential gene expression provides leads to environmentally regulated soybean seed protein content

Frontiers in Plant Science, 2023
Soybean is an important global source of plant-based protein. A persistent trend has been observed over the past two decades that soybeans grown in western Canada have lower seed protein content than soybeans grown in eastern Canada.
Julia C. Hooker, Julia C. Hooker, Myron Smith, Gerardo Zapata, Martin Charette, Doris Luckert, Ramona M. Mohr, Ketema A. Daba, Thomas D. Warkentin, Mehri Hadinezhad, Brent Barlow, Anfu Hou, François Lefebvre, Ashkan Golshani, Elroy R. Cober, Bahram Samanfar, Bahram Samanfar   +16 more
doaj   +1 more source

Accounting for environmental variation in the free asparagine content of wheat grain

, 2023
The free (soluble, non-protein) asparagine content of wheat grain can vary massively due to environmental factors and agronomic differences in how the crop is grown.
Elmore, S., Halford, N. G., Oddy, J.
core   +1 more source

Characterization of Three L-Asparaginases from Maritime Pine (Pinus pinaster Ait.)

Frontiers in Plant Science, 2017
Asparaginases (ASPG, EC 3.5.1.1) catalyze the hydrolysis of the amide group of L-asparagine producing L-aspartate and ammonium. Three ASPG, PpASPG1, PpASPG2, and PpASPG3, have been identified in the transcriptome of maritime pine (Pinus pinaster Ait ...
Sonia H. Van Kerckhoven, Fernando N. de la Torre, Rafael A. Cañas, Concepción Avila, Francisco R. Cantón, Francisco M. Cánovas   +5 more
doaj   +1 more source

Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy

Pharmaceuticals, 2021
Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids that can be produced in our body. However, they are essential for the growth of highly proliferative cells such as cancers.
Macus Tien Kuo, Helen H. W. Chen, Lynn G. Feun, Niramol Savaraj   +3 more
doaj   +1 more source

Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues

EMBO Journal, 2021
Brown and beige fat are specialized for energy expenditure by dissipating energy from glucose and fatty acid oxidation as heat. While glucose and fatty acid metabolism have been extensively studied in thermogenic adipose tissues, the involvement of amino
Yingjiang Xu, Ting Shi, Xuan Cui, Linyu Yan, Qi Wang, Xiao-Yan Xu, Qingwen Zhao, Xiao-Xuan Xu, Qi-Qun Tang, Huiru Tang, Dong-Ning Pan   +10 more
semanticscholar   +1 more source