Proline: The Distribution, Frequency, Positioning, and Common Functional Roles of Proline and Polyproline Sequences in the Human Proteome [PDF]
PLoS ONE, 2013 Proline is an anomalous amino acid. Its nitrogen atom is covalently locked within a ring, thus it is the only proteinogenic amino acid with a constrained phi angle.
Alexander A Morgan, Edward Rubenstein
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Auxotrophy from bioenergetic demand: the case of proline addiction in Clostridioides difficile [PDF]
mSphereMany microbial growth requirements are interpreted as auxotrophy arising from loss of biosynthetic capacity. Clostridioides difficile is widely considered to be proline auxotrophic because it fails to grow in defined media lacking proline, yet it harbors
Michael A. Johnstone, William T. Self
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Dynamic Proline Metabolism: Importance and Regulation in Water Limited Environments
Frontiers in Plant Science, 2015 Drought-induced proline accumulation observed in many plant species has led to the hypothesis that further increases in proline accumulation would promote drought tolerance.
Paul Edwin Verslues, Govinal B Bhaskara
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Sources of Superoxide/H2O2 During Mitochondrial Proline Oxidation
Redox Biology, 2014 p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis.
Christopher C Benz +2 more
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Connecting Proline Metabolism and Signaling Pathways in Plant Senescence
Frontiers in Plant Science, 2015 The amino acid proline has a unique biological role in stress adaptation. Proline metabolism is manipulated under stress by multiple and complex regulatory pathways and can profoundly influence cell death and survival in microorganisms, plants, and ...
Lu Zhang, Donald F Becker
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Proline protects Wickerhamomyces anomalus against ethanol‑induced damage during logarithmic growth: integrated physiological, transcriptomic, and metabolomic analyses [PDF]
BMC MicrobiologyBackground Proline plays a critical regulatory role in microbial stress responses; however, its specific mechanism of action under ethanol stress in Wickerhamomyces anomalus during logarithmic growth remains poorly understood.
Xiaozhu Liu +4 more
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Biomolecules, 2021 L-proline (proline) is a key regulator of embryogenesis, placental development, and fetal growth. However, the underlying mechanisms that support the beneficial effects of proline are largely unknown.
Ning Liu +7 more
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Current Plant Biology, 2023 Proline/P5C cycle between mitochondria and cytosol, play important roles in energy supply and ROS (Reactive oxygen species) generation in mammalian cell.
Wenhan Ying +6 more
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The sodium/proline transporter PutP of Helicobacter pylori. [PDF]
PLoS ONE, 2013 Helicobacter pylori is cause of chronic gastritis, duodenal ulcer and gastric carcinoma in humans. L-proline is a preferred energy source of the microaerophilic bacterium. Previous analyses revealed that HpputP and HpputA, the genes that are predicted to
Araceli Rivera-Ordaz +8 more
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Proline Transport and Growth Changes in Proline Transport Mutants of Staphylococcus aureus
Microorganisms, 2022 Staphylococcus aureus is a major cause of skin/soft tissue infections and more serious infections in humans. The species usually requires the importation of proline to be able to survive. Previous work has shown that single mutations in genes that encode
William R. Schwan
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