Results 1 to 10 of about 88,584 (246)

Proline Dehydrogenase and Pyrroline 5 Carboxylate Dehydrogenase from Mycobacterium tuberculosis: Evidence for Substrate Channeling [PDF]

Pathogens, 2023
In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and ∆1-pyrroline-5-carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline oxidation to glutamate via the intermediates P5C and L-glutamate-γ-semialdehyde.
Santosh Kumar, Steven Sega, Jamie K. Lynn-Barbe, Dannika L. Harris, Jordan T. Koehn, Debbie C. Crans, Dean C. Crick   +6 more
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Can proline dehydrogenase—a key enzyme involved in proline metabolism—be a novel target for cancer therapy? [PDF]

Frontiers in Oncology, 2023
Emerging evidence suggests that proline metabolism is important for regulating the survival and death of different types of cancer cells. Proline dehydrogenase (PRODH), an enzyme catalyzing proline catabolism, and the degradation products of proline by ...
Xiangyuan Xu, Xiangyuan Xu, Guangtao Zhang, Yijia Chen, Weina Xu, Yujing Liu, Yujing Liu, Guang Ji, Guang Ji, Hanchen Xu, Hanchen Xu   +10 more
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Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase [PDF]

Molecules
The proline catabolic pathway consisting of proline dehydrogenase (PRODH) and L-glutamate-γ-semialdehyde (GSAL) dehydrogenase (GSALDH) catalyzes the four-electron oxidation of L-proline to L-glutamate. Chemical probes to these enzymes are of interest for
Kaylen R. Meeks, Alexandra N. Bogner, Jay C. Nix, John J. Tanner   +3 more
doaj   +4 more sources

Proline Protects Boar Sperm against Oxidative Stress through Proline Dehydrogenase-Mediated Metabolism and the Amine Structure of Pyrrolidine [PDF]

Animals, 2020
Proline was reported to improve sperm quality in rams, stallions, cynomolgus monkeys, donkeys, and canines during cryopreservation. However, the underlying mechanism remains unclear.
Chengwen Feng, Zhendong Zhu, Wenjing Bai, Rongnan Li, Yi Zheng, Xiu’e Tian, De Wu, Hongzhao Lu, Yongjun Wang, Wenxian Zeng   +9 more
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Appropriate Activity Assays Are Crucial for the Specific Determination of Proline Dehydrogenase and Pyrroline-5-Carboxylate Reductase Activities [PDF]

Frontiers in Plant Science, 2020
Accumulation of proline is a widespread plant response to a broad range of environmental stress conditions including salt and osmotic stress. Proline accumulation is achieved mainly by upregulation of proline biosynthesis in the cytosol and by inhibition
Sandrine Lebreton, Cécile Cabassa-Hourton, Arnould Savouré, Dietmar Funck, Giuseppe Forlani   +4 more
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Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus [PDF]

Molecules, 2018
Proline dehydrogenase (ProDH) is a ubiquitous flavoenzyme that catalyzes the oxidation of proline to Δ1-pyrroline-5-carboxylate. Thermus thermophilus ProDH (TtProDH) contains in addition to its flavin-binding domain an N-terminal arm, consisting of ...
Mieke M. E. Huijbers, Ilona van Alen, Jenny W. Wu, Arjan Barendregt, Albert J. R. Heck, Willem J. H. van Berkel   +5 more
doaj   +2 more sources

Proline dehydrogenase regulates redox state and respiratory metabolism in Trypanosoma cruzi. [PDF]

PLoS ONE, 2013
Over the past three decades, L-proline has become recognized as an important metabolite for trypanosomatids. It is involved in a number of key processes, including energy metabolism, resistance to oxidative and nutritional stress and osmoregulation.
Lisvane Silva Paes, Brian Suárez Mantilla, Flávia Menezes Zimbres, Elisabeth Mieko Furusho Pral, Patrícia Diogo de Melo, Erich B Tahara, Alicia J Kowaltowski, Maria Carolina Elias, Ariel Mariano Silber   +8 more
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Measurement of δ¹-Pyrroline-5-Carboxylic Acid in Plant Extracts for Physiological and Biochemical Studies [PDF]

Metabolites
Background/Objectives: δ1-Pyrroline-5-carboxylic acid (P5C) is a key intermediate in both the pathways leading in plants to proline synthesis, as well as in the proline catabolic route that takes place in the mitochondrion.
Giuseppe Forlani, Flavia Trupia
doaj   +2 more sources

Exogenous Proline Alleviated Low Temperature Stress in Maize Embryos by Optimizing Seed Germination, Inner Proline Metabolism, Respiratory Metabolism and a Hormone Regulation Mechanism

Agriculture, 2022
Proline (Pro) is not only an important osmotic adjustment substance, but it also plays an important role in regulating plant abiotic stress resistance. The maize varieties, Xinxin 2 (low temperature insensitive) and Damin 3307 (low temperature sensitive),
Shiyu Zuo, Jing Li, Wanrong Gu, Shi Wei
doaj   +1 more source

Intriguing Role of Proline in Redox Potential Conferring High Temperature Stress Tolerance

Frontiers in Plant Science, 2022
Proline is a proteinogenic amino acid synthesized from glutamate and ornithine. Pyrroline-5-carboxylate synthetase and pyrroline-5-carboxylate reductase are the two key enzymes involved in proline synthesis from glutamate.
P. B. Kavi Kishor, Prashanth Suravajhala, P. Rathnagiri, Nese Sreenivasulu   +3 more
doaj   +1 more source